Ser307
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Home > Phosphorylation Site Page: > Ser307  -  LKB1 (human)

Site Information
IRQIRQHsWFRkKHP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7710000

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCZ (human) ( 2 )
Kinases, in vitro:
PKCZ (human) ( 2 )
Treatments:
2-deoxyglucose ( 2 ) , acadesine ( 2 ) , leptin ( 2 ) , metformin ( 2 ) , ONOO(-) ( 2 ) , PKC-zeta_inhibitor ( 2 ) , siRNA ( 2 ) , statin ( 2 )

Downstream Regulation
Effects of modification on LKB1:
intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , cell growth, altered ( 2 )
Induce interaction with:
AMPKA1 (human) ( 2 ) , Exportin-1 (human) ( 2 ) , STRAD (human) ( 2 )

References 

1

Zhu H, et al. (2013) Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation. J Biol Chem 288, 16495-505
23612973   Curated Info

2

Xie Z, et al. (2009) Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Mol Cell Biol 29, 3582-96
19414597   Curated Info