Tyr428
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr428  -  G6PD (human)

Site Information
DLtyGNRyKNVkLPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7705803

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
EC (endothelial) ( 2 ) , HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 )
Treatments:
VEGF ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 2 )

References 

1

Ma H, et al. (2021) c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene
33686238   Curated Info

2

Pan S, World CJ, Kovacs CJ, Berk BC (2009) Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells. Arterioscler Thromb Vasc Biol 29, 895-901
19359662   Curated Info