Thr620
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Home > Phosphorylation Site Page: > Thr620  -  BUB1B (human)

Site Information
RAARFVStPFHEIMS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 767908

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 2 , 3 ) , Hela_FlpIn (cervical) ( 2 )

Upstream Regulation
Treatments:
calyculin_A ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on BUB1B:
molecular association, regulation ( 2 , 3 ) , phosphorylation ( 1 , 2 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 , 3 ) , cytoskeletal reorganization ( 3 ) , signaling pathway regulation ( 2 )
Induce interaction with:
PLK1 (human) ( 2 , 3 )

References 

1

Corno A, et al. (2023) A bifunctional kinase-phosphatase module balances mitotic checkpoint strength and kinetochore-microtubule attachment stability. EMBO J, e112630
37712330   Curated Info

2

Cordeiro MH, Smith RJ, Saurin AT (2020) Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint. J Cell Biol 219
33125045   Curated Info

3

Elowe S, et al. (2007) Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev 21, 2205-19
17785528   Curated Info

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