Ser198
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Home > Phosphorylation Site Page: > Ser198  -  Tau iso8 (human)

Site Information
sGDRsGyssPGsPGt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449551

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 8 ) , electrophoretic mobility shift ( 5 ) , mass spectrometry ( 4 , 5 , 8 ) , microscopy-colocalization with upstream kinase ( 7 ) , phospho-antibody ( 3 , 5 , 6 ) , western blotting ( 3 , 8 )
Disease tissue studied:
Alzheimer's disease ( 4 , 8 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 3 ) , brain ( 4 , 8 ) , COS (fibroblast) ( 5 ) , neuron-brain ( 7 ) , SH-SY5Y (neural crest) ( 5 , 6 )

Upstream Regulation
Regulatory protein:
WWOX (human) ( 7 )
Putative in vivo kinases:
TTBK1 (human) ( 5 )
Kinases, in vitro:
TTBK1 (human) ( 5 )
Treatments:
lithium ( 6 ) , PD98059 ( 6 ) , SP600125 ( 7 ) , tungstate ( 6 )

Downstream Regulation
Effects of modification on Tau iso8:
molecular association, regulation ( 5 , 7 )
Induce interaction with:
Tau (human) ( 5 ) , WWOX (human) ( 7 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 3 , 7 , 8 )

References 

1

Luo HB, et al. (2014) SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A 111, 16586-91
25378699   Curated Info

2

Luo Y, et al. (2013) PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta 1833, 1235-43
23428800   Curated Info

3

Duka V, et al. (2013) Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. PLoS One 8, e75025
24073234   Curated Info

4

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

5

Sato S, Cerny RL, Buescher JL, Ikezu T (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem 98, 1573-84
16923168   Curated Info

6

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

7

Sze CI, et al. (2004) Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem 279, 30498-506
15126504   Curated Info

8

Hanger DP, et al. (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem 71, 2465-76
9832145   Curated Info