Ser341
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Home > Phosphorylation Site Page: > Ser341  -  SSTR2 (rat)

Site Information
GAEDGERsDsKQDKs   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7652103

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GRK2 (human) ( 4 )
Treatments:
KE108 ( 2 ) , octreotide ( 3 ) , pasireotide ( 2 , 3 ) , SST14 ( 2 , 3 , 4 )

References 

1

Pöll F, Doll C, Schulz S (2011) Rapid Dephosphorylation of G Protein-coupled Receptors by Protein Phosphatase 1{beta} Is Required for Termination of {beta}-Arrestin-dependent Signaling. J Biol Chem 286, 32931-6
21795688   Curated Info

2

Kao YJ, Ghosh M, Schonbrunn A (2011) Ligand-Dependent Mechanisms of sst2A Receptor Trafficking: Role of Site-Specific Phosphorylation and Receptor Activation in the Actions of Biased Somatostatin Agonists. Mol Endocrinol 25, 1040-54
21493671   Curated Info

3

Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66
21330405   Curated Info

4

Liu Q, Bee MS, Schonbrunn A (2009) Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation. Mol Pharmacol 76, 68-80
19389921   Curated Info