Ser343

Site Information
EDGERsDsKQDKsRL SwissProt
Blast this site against: NCBI SwissProt PDB
Site Group ID: 7652105

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 , 3 , 4 ) , CHO (fibroblast) ( 2 , 4 ) , GH4C1 (pituitary cell) [SSTR2 (rat), transfection] ( 4 )

Upstream Regulation
Putative in vivo kinases:	GRK2 (human) ( 4 ) , PKCA (human) ( 4 )
Treatments:	GF109203X ( 4 ) , KE108 ( 2 ) , octreotide ( 3 ) , pasireotide ( 2 , 3 ) , phorbol_ester ( 4 ) , PTX ( 4 ) , SST14 ( 2 , 3 , 4 )

References
1	Pöll F, Doll C, Schulz S (2011) Rapid Dephosphorylation of G Protein-coupled Receptors by Protein Phosphatase 1{beta} Is Required for Termination of {beta}-Arrestin-dependent Signaling. J Biol Chem 286, 32931-6 21795688 Curated Info
2	Kao YJ, Ghosh M, Schonbrunn A (2011) Ligand-Dependent Mechanisms of sst2A Receptor Trafficking: Role of Site-Specific Phosphorylation and Receptor Activation in the Actions of Biased Somatostatin Agonists. Mol Endocrinol 25, 1040-54 21493671 Curated Info
3	Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66 21330405 Curated Info
4	Liu Q, Bee MS, Schonbrunn A (2009) Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation. Mol Pharmacol 76, 68-80 19389921 Curated Info