Ser343
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Home > Phosphorylation Site Page: > Ser343  -  SSTR2 (human)

Site Information
DDGERsDsKQDKSRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7652105

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 5 ) , mutation of modification site ( 2 , 7 ) , phospho-antibody ( 1 , 3 , 4 , 5 , 6 , 7 ) , western blotting ( 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:
neuroendocrine cancer ( 5 ) , pancreatic cancer ( 1 ) , pancreatic islet cell cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 , 4 , 5 , 6 ) , bile-ducts ( 5 ) , CHO (fibroblast) ( 7 ) , ileum ( 5 ) , liver ( 5 ) , pancreas ( 1 ) , pancreatic islet ( 5 )

Upstream Regulation
Putative in vivo kinases:
GRK3 (human) ( 6 )
Treatments:
Coy-14 ( 5 , 7 ) , octreotide ( 1 , 5 , 6 ) , pasireotide ( 1 , 6 ) , SST14 ( 2 , 3 , 4 , 7 )

Downstream Regulation
Effects of modification on SSTR2:
receptor desensitization, induced ( 2 ) , receptor internalization, altered ( 6 , 7 ) , receptor internalization, induced ( 1 , 2 , 3 , 5 ) , receptor recycling, induced ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
neuroendocrine cancer ( 5 )

References 

1

Mohamed A, et al. (2014) Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures. Endocr Relat Cancer 21, 691-704
25012983   Curated Info

2

Lehmann A, et al. (2014) Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor. Mol Cell Endocrinol 387, 44-51
24565897   Curated Info

3

Lehmann A, et al. (2014) Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms. PLoS One 9, e91526
24637622   Curated Info

4

Petrich A, et al. (2013) Phosphorylation of Threonine 333 Regulates Trafficking of the Human sst5 Somatostatin Receptor. Mol Endocrinol 27, 671-82
23418396   Curated Info

5

Waser B, et al. (2012) Phosphorylation of sst2 receptors in neuroendocrine tumors after octreotide treatment of patients. Am J Pathol 180, 1942-9
22538189   Curated Info

6

Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66
21330405   Curated Info

7

Ghosh M, Schonbrunn A (2011) Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation. J Biol Chem 286, 13561-73
21343287   Curated Info

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