Thr353
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Home > Phosphorylation Site Page: > Thr353  -  SSTR2 (human)

Site Information
DKSRLNEttEtQRtL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7652102

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mutation of modification site ( 1 , 5 ) , phospho-antibody ( 2 , 3 , 5 ) , western blotting ( 2 , 3 , 5 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 , 3 ) , CHO (fibroblast) ( 5 ) , Jurkat (T lymphocyte) ( 4 )

Upstream Regulation
Treatments:
Coy-14 ( 5 ) , SST14 ( 1 , 2 , 3 , 5 )

Downstream Regulation
Effects of modification on SSTR2:
receptor desensitization, induced ( 1 ) , receptor internalization, induced ( 1 , 2 ) , receptor recycling, induced ( 2 )

References 

1

Lehmann A, et al. (2014) Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor. Mol Cell Endocrinol 387, 44-51
24565897   Curated Info

2

Lehmann A, et al. (2014) Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms. PLoS One 9, e91526
24637622   Curated Info

3

Petrich A, et al. (2013) Phosphorylation of Threonine 333 Regulates Trafficking of the Human sst5 Somatostatin Receptor. Mol Endocrinol 27, 671-82
23418396   Curated Info

4

Zhou J (2011) CST Curation Set: 12496; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Ghosh M, Schonbrunn A (2011) Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation. J Biol Chem 286, 13561-73
21343287   Curated Info

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