Thr389
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Home > Phosphorylation Site Page: > Thr389  -  p70S6K iso2 (rat)

Site Information
NQVFLGFtYVAPSVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448607

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
L6 (myoblast) ( 2 )

Upstream Regulation
Treatments:
glucose_starvation ( 5 ) , insulin ( 5 ) , PD98059 ( 5 ) , rapamycin ( 2 , 5 ) , refeeding ( 2 ) , serum_starvation ( 2 ) , wortmannin ( 5 )

References 

1

Lee Hamilton D, et al. (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab 307, E365-73
24961241   Curated Info

2

Kakade D, Islam N, Maeda N, Adegoke OA (2014) Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes. BMC Cell Biol 15, 2
24405715   Curated Info

3

Monteserin-Garcia J, et al. (2013) Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis. FASEB J 27, 1561-71
23292070   Curated Info

4

Park JH, Arakawa-Takeuchi S, Jinno S, Okayama H (2011) Rho-associated Kinase Connects a Cell Cycle-controlling Anchorage Signal to the Mammalian Target of Rapamycin Pathway. J Biol Chem 286, 23132-41
21561859   Curated Info

5

Giraud J, et al. (2007) Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol 21, 2294-302
17579213   Curated Info