Ser424
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Home > Phosphorylation Site Page: > Ser424  -  p70S6K iso2 (rat)

Site Information
GSPRtPVsPVKFSPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448357
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
VSMC-aorta ( 1 )

Upstream Regulation
Regulatory protein:
5-HT(2A) (human) ( 1 )
Treatments:
5-HT ( 1 ) , LY294002 ( 1 ) , rapamycin ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on p70S6K iso2:
activity, induced ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 )

References 

1

Liu Y, Fanburg BL (2006) Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Am J Respir Cell Mol Biol 34, 182-91
16195541   Curated Info