Thr153
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Home > Phosphorylation Site Page: > Thr153  -  Tau iso8 (human)

Site Information
DGKtKIAtPRGAAPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449076

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , mass spectrometry ( 3 )
Disease tissue studied:
Alzheimer's disease ( 3 ) , neuroblastoma ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
LRRK2 (human) ( 2 )
Kinases, in vitro:
CDK1 (human) ( 5 ) , CDK5 (human) ( 5 ) , ERK1 (human) ( 4 , 5 ) , ERK2 (human) ( 1 , 5 ) , GSK3B (human) ( 4 )

Downstream Regulation
Effects of modification on Tau iso8:
molecular association, regulation ( 2 )
Induce interaction with:
Tau iso8 (human) ( 2 )

References 

1

Qi H, et al. (2016) Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. J Biol Chem 291, 7742-53
26858248   Curated Info

2

Bailey RM, et al. (2013) LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathol 126, 809-27
24113872   Curated Info

3

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

4

Schneider A, et al. (1999) Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38, 3549-58
10090741   Curated Info

5

Illenberger S, et al. (1998) The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell 9, 1495-512
9614189   Curated Info