Thr32
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Home > Phosphorylation Site Page: > Thr32  -  FOXO3A (rat)

Site Information
QSRPRSCtWPLQRPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448602

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
adrenal cancer ( 3 ) , pheochromocytoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , L6 (myoblast) ( 2 ) , neuron-'brain, cerebral cortex' ( 1 ) , PC-12 (chromaffin) ( 3 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (rat) ( 3 )
Kinases, in vitro:
Akt1 (human) ( 3 )
Treatments:
API-2 ( 2 ) , depolarization ( 1 ) , IGF-1 ( 1 , 3 ) , insulin ( 2 ) , LY294002 ( 1 , 3 ) , PD98059 ( 3 ) , PIK90 ( 2 ) , PP242 ( 2 ) , rapamycin ( 2 , 3 ) , wortmannin ( 1 , 3 )

References 

1

Song B, et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J Biol Chem 285, 41122-34
20841359   Curated Info

2

Feldman ME, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7, e38
19209957   Curated Info

3

Zheng WH, Kar S, Quirion R (2000) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275, 39152-8
10995739   Curated Info