Ser372

Site Information
IsPMRsIsENsLVAM SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 7611001

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mutation of modification site ( 6 )
Disease tissue studied:	breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , hepatocellular carcinoma, surrounding tissue ( 5 ) , lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 4 ) , pancreatic ductal adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:	'pancreatic, ductal'-pancreas ( 3 ) , breast ( 1 , 2 ) , COS (fibroblast) ( 6 ) , hepatocyte-liver ( 5 ) , lung ( 4 ) , MEF (fibroblast) ( 6 ) , oocyte ( 6 )

Downstream Regulation
Effects of modification on GRB14:	molecular association, regulation ( 6 )
Effects of modification on biological processes:	cell cycle regulation ( 6 ) , cell growth, altered ( 6 )
Induce interaction with:	INSR (human) ( 6 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948 24670416 Curated Info
4	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
5	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
6	Goenaga D, et al. (2009) Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol 23, 1043-51 19359342 Curated Info