Thr50
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Home > Phosphorylation Site Page: > Thr50  -  Tau iso8 (human)

Site Information
LkEsPLQtPtEDGsE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447931

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , mass spectrometry ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
Alzheimer's disease ( 1 ) , neuroblastoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
ERK1 (human) ( 3 ) , ERK2 (human) ( 3 ) , GSK3B (human) ( 3 )

References 

1

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

2

Feijoo C, et al. (2005) Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. J Cell Sci 118, 397-408
15632108   Curated Info

3

Illenberger S, et al. (1998) The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell 9, 1495-512
9614189   Curated Info