Ser46
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Home > Phosphorylation Site Page: > Ser46  -  Tau iso8 (human)

Site Information
tDAGLkEsPLQtPtE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447926

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , mass spectrometry ( 1 , 2 ) , phospho-antibody ( 1 )
Disease tissue studied:
Alzheimer's disease ( 2 ) , neuroblastoma ( 3 ) , PSP ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
ERK1 (human) ( 3 ) , ERK2 (human) ( 3 ) , GSK3B (human) ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
PSP ( 1 )

References 

1

Wray S, Saxton M, Anderton BH, Hanger DP (2008) Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats. J Neurochem 105, 2343-52
18315566   Curated Info

2

Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708   Curated Info

3

Illenberger S, et al. (1998) The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell 9, 1495-512
9614189   Curated Info