Thr393
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Home > Phosphorylation Site Page: > Thr393  -  CTNNB1 (human)

Site Information
RNLSDAAtkQEGMEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449562

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (mouse) ( 2 )
Treatments:
apigenin ( 2 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on CTNNB1:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, induced ( 2 )
Inhibit interaction with:
axin 1 (human) ( 1 )

References 

1

Wu H, Symes K, Seldin DC, Dominguez I (2009) Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem 108, 52-63
19565571   Curated Info

2

Song DH, et al. (2003) CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem 278, 24018-25
12700239   Curated Info