Ser45
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Home > Phosphorylation Site Page: > Ser45  -  CTNNB1 (rat)

Site Information
GATtTAPsLSGKGNP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447488

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 , 4 )
Disease tissue studied:
colorectal cancer ( 5 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , colon ( 5 ) , HEK293T (epithelial) ( 4 ) , neuron ( 1 ) , Rat1 (fibroblast) ( 4 )

Upstream Regulation
Regulatory protein:
APP (human) ( 1 )
Putative in vivo kinases:
CDK2 (human) ( 4 )
Kinases, in vitro:
CDK2 (mouse) ( 4 ) , CK1A (human) ( 2 ) , GSK3B (rat) ( 3 )
Treatments:
lithium ( 3 ) , LLnL ( 3 )

Downstream Regulation
Effects of modification on CTNNB1:
protein degradation ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal cancer ( 5 )

References 

1

Chen Y, Bodles AM (2007) Amyloid precursor protein modulates beta-catenin degradation. J Neuroinflammation 4, 29
18070361   Curated Info

2

Bustos VH, et al. (2006) The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1. Proc Natl Acad Sci U S A 103, 19725-30
17172446   Curated Info

3

Al-Fageeh M, et al. (2004) Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene 23, 4839-46
15064718   Curated Info

4

Park CS, et al. (2004) Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. J Biol Chem 279, 19592-9
14985333   Curated Info

5

Blum CA, et al. (2001) beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis 22, 315-20
11181454   Curated Info