Ser33
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Home > Phosphorylation Site Page: > Ser33  -  CTNNB1 (rat)

Site Information
QQQSYLDsGIHsGAT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447487

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 5 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 3 ) , 293 (epithelial) ( 4 ) , 293T (epithelial) ( 5 ) , 3Y1 (fibroblast) ( 1 ) , COS (fibroblast) ( 1 ) , HFFF-2 (fibroblast) ( 1 ) , neuron ( 2 ) , Rat1 (fibroblast) ( 5 )

Upstream Regulation
Regulatory protein:
APP (human) ( 2 )
Putative in vivo kinases:
CDK2 (human) ( 5 ) , GSK3B (rat) ( 1 )
Kinases, in vitro:
CDK2 (mouse) ( 5 ) , GSK3B (rat) ( 4 )
Treatments:
exercise ( 3 ) , insulin ( 3 ) , lithium ( 1 , 4 ) , LLnL ( 4 ) , MG132 ( 5 ) , seliciclib ( 5 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 5 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Huang P, Senga T, Hamaguchi M (2007) A novel role of phospho-beta-catenin in microtubule regrowth at centrosome. Oncogene 26, 4357-71
17260019   Curated Info

2

Chen Y, Bodles AM (2007) Amyloid precursor protein modulates beta-catenin degradation. J Neuroinflammation 4, 29
18070361   Curated Info

3

Aschenbach WG, et al. (2006) Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Am J Physiol Endocrinol Metab 291, E152-8
16478782   Curated Info

4

Al-Fageeh M, et al. (2004) Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene 23, 4839-46
15064718   Curated Info

5

Park CS, et al. (2004) Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. J Biol Chem 279, 19592-9
14985333   Curated Info