Thr616
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Home > Phosphorylation Site Page: > Thr616  -  SERT (human)

Site Information
IKsItPEtPTEIPCG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7576402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CHO (fibroblast) ( 2 ) , COS (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 ) , JNK2 (human) ( 1 ) , P38A (human) ( 1 )

Downstream Regulation
Effects of modification on SERT:
intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Inhibit interaction with:
Vimentin (human) ( 2 )

References 

1

Sørensen L, Strømgaard K, Kristensen AS (2014) Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. ACS Chem Biol 9, 935-44
24450286   Curated Info

2

Ahmed BA, et al. (2009) The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS One 4, e4730
19270731   Curated Info

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