Ser525
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Home > Phosphorylation Site Page: > Ser525  -  ASIC1 iso1 (human)

Site Information
QKEAKRSsADKGVAL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449558

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal'-brain ( 1 ) , COS (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 1 )
Treatments:
colforsin ( 1 ) , IBMX ( 1 ) , KT5720 ( 1 )

Downstream Regulation
Effects of modification on ASIC1 iso1:
molecular association, regulation ( 1 )
Inhibit interaction with:
PICK1 (human) ( 1 )

References 

1

Leonard AS, et al. (2003) cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A 100, 2029-34
12578970   Curated Info