Tyr273
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Home > Phosphorylation Site Page: > Tyr273  -  FCGR2B iso2 (human)

Site Information
GAENTITySLLMHPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448507

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , neuron-'brain, hippocampus' ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Treatments:
beta-amyloid_42 ( 1 )

Downstream Regulation
Effects of modification on FCGR2B iso2:
molecular association, regulation ( 1 )
Induce interaction with:
SHP-2 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Kam TI, et al. (2016) FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. Elife 5
27834631   Curated Info

2

Bewarder N, et al. (1996) In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. Mol Cell Biol 16, 4735-43
8756631   Curated Info