Ser510
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Home > Phosphorylation Site Page: > Ser510  -  Tau (rat)

Site Information
GERSGyssPGsPGtP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447927

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 19 ) , immunoprecipitation ( 11 ) , mass spectrometry ( 7 ) , peptide sequencing ( 19 ) , phospho-antibody ( 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ) , phosphoamino acid analysis ( 19 ) , western blotting ( 2 , 6 , 8 , 9 , 10 , 11 , 15 , 16 )
Disease tissue studied:
Alzheimer's disease ( 9 , 13 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 7 ) , 'brain, cerebellum' ( 7 ) , 'brain, cerebral cortex' ( 7 ) , 'brain, hippocampus' ( 8 , 11 , 15 ) , 'neuron, cerebellar granule'-brain ( 13 ) , 'neuron, cortical'-brain ( 18 ) , 'neuron, hippocampal' ( 6 ) , adipose tissue ( 7 ) , blood ( 7 ) , brain ( 9 , 10 , 16 , 17 , 19 ) , heart ( 7 ) , intestine ( 7 ) , kidney ( 7 ) , liver ( 7 ) , lung ( 7 ) , muscle ( 7 ) , neuron-'brain, cerebral cortex' ( 2 ) , testis ( 7 )

Upstream Regulation
Putative upstream phosphatases:
PPP2CA (rat) ( 11 )
Treatments:
anoxia ( 13 ) , beta-amyloid_25-35 ( 18 ) , calyculin_A ( 8 ) , Cdk2/5_inhibitor ( 16 ) , colchicine ( 18 ) , colforsin ( 16 ) , DON ( 10 ) , fasting ( 10 ) , folic acid ( 11 ) , ginsenoside ( 2 ) , glutamic acid ( 18 ) , H-CHO ( 12 ) , homocysteine ( 11 ) , hypoxia ( 3 ) , ischemic stroke ( 2 ) , isoproterenol ( 15 ) , lithium ( 16 ) , low_glucose ( 13 ) , LY294002 ( 2 ) , melatonin ( 15 ) , memantine ( 6 ) , okadaic_acid ( 6 , 9 , 10 , 17 , 18 ) , PD98059 ( 16 ) , PUGNAc ( 17 ) , Rp-cAMPS ( 16 ) , SB203580 ( 16 ) , tungstate ( 12 ) , vitamin_B12 ( 11 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 6 , 15 )

References 

1

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

2

Zhang X, et al. (2014) Ginsenoside Rd attenuates tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after transient forebrain ischemia. Neurochem Res 39, 1363-73
24792734   Curated Info

3

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

4

Liu X, et al. (2014) Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis 40, 419-27
24448782   Curated Info

5

Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info

6

Zimmer ER, et al. (2012) Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic Acid administration in rats. Curr Alzheimer Res 9, 1182-90
22515493   Curated Info

7

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

8

Yang X, et al. (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25, 1118-25
20542922   Curated Info

9

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

10

Liu F, et al. (2009) Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain 132, 1820-32
19451179   Curated Info

11

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

12

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

13

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

14

Yamamoto H, et al. (2005) Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain. J Neurochem 94, 1438-47
16000144   Curated Info

15

Wang XC, et al. (2005) Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng Li Xue Bao 57, 7-12
15719129   Curated Info

16

Liu SJ, et al. (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-88
15375165   Curated Info

17

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info

18

Davis DR, et al. (1995) The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures. Biochem J 309 ( Pt 3), 941-9
7639714   Curated Info

19

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info