Ser509
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Home > Phosphorylation Site Page: > Ser509  -  Tau (rat)

Site Information
SGERSGyssPGsPGt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449551

In vivo Characterization
Methods used to characterize site in vivo:
amino acid analysis ( 7 ) , mass spectrometry ( 3 ) , peptide sequencing ( 7 ) , phospho-antibody ( 1 , 4 , 5 , 6 ) , phosphoamino acid analysis ( 7 ) , western blotting ( 1 , 4 , 6 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 3 ) , 'brain, cerebellum' ( 3 ) , 'brain, cerebral cortex' ( 3 ) , 'brain, hippocampus' ( 4 ) , adipose tissue ( 3 ) , blood ( 3 ) , brain ( 6 , 7 ) , heart ( 3 ) , intestine ( 3 ) , kidney ( 3 ) , liver ( 3 ) , lung ( 3 ) , muscle ( 3 ) , neuron-'brain, hippocampus' ( 1 ) , testis ( 3 )

Upstream Regulation
Treatments:
calyculin_A ( 4 ) , Cdk2/5_inhibitor ( 6 ) , colforsin ( 6 ) , H-CHO ( 5 ) , hypoxia ( 2 ) , lithium ( 6 ) , PD98059 ( 6 ) , Rp-cAMPS ( 6 ) , SB203580 ( 6 ) , tungstate ( 5 )

References 

1

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

2

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

3

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

4

Yang X, et al. (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25, 1118-25
20542922   Curated Info

5

Gómez-Ramos A, et al. (2006) Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation. J Neurosci Res 83, 264-73
16397900   Curated Info

6

Liu SJ, et al. (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-88
15375165   Curated Info

7

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info