Thr203

Site Information
HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447542

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 468 , 544 ) , flow cytometry ( 25 , 51 , 80 , 100 , 211 , 251 , 266 , 387 ) , immunoassay ( 6 , 20 , 21 , 23 , 24 , 37 , 44 , 50 , 51 , 55 , 65 , 66 , 67 , 81 , 82 , 97 , 98 , 99 , 124 , 132 , 148 , 200 , 233 ) , immunoprecipitation ( 113 , 116 , 121 , 151 , 156 , 254 , 291 , 302 , 316 , 548 ) , mass spectrometry ( 30 , 42 , 109 , 114 , 115 , 127 , 140 , 159 , 160 , 161 , 162 , 165 , 169 , 171 , 174 , 175 , 177 , 178 , 186 , 187 , 188 , 189 , 190 , 191 , 205 , 206 , 220 , 232 , 246 , 247 , 256 , 257 , 258 , 265 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 283 , 284 , 286 , 287 , 288 , 294 , 295 , 296 , 308 , 310 , 311 , 312 , 313 , 322 , 323 , 324 , 325 , 326 , 331 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 341 , 342 , 343 , 345 , 346 , 348 , 349 , 350 , 351 , 352 , 354 , 355 , 356 , 358 , 359 , 362 , 363 , 364 , 365 , 366 , 367 , 372 , 376 , 377 , 378 , 383 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 , 404 , 407 , 411 , 412 , 413 , 414 , 415 , 416 , 421 , 446 ) , mass spectrometry (in vitro) ( 249 ) , microscopy-colocalization with upstream kinase ( 523 ) , modification-specific antibody ( 96 , 105 ) , multiple reaction monitoring (MRM) ( 30 ) , mutation of modification site ( 113 , 116 , 121 , 316 , 318 , 360 , 369 , 439 , 442 , 468 , 471 , 472 , 499 ) , peptide sequencing ( 452 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 87 , 88 , 89 , 90 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 106 , 108 , 110 , 111 , 113 , 116 , 117 , 118 , 119 , 120 , 121 , 123 , 124 , 125 , 126 , 129 , 131 , 132 , 133 , 134 , 135 , 137 , 138 , 139 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 155 , 156 , 157 , 158 , 163 , 164 , 166 , 167 , 168 , 170 , 172 , 176 , 179 , 180 , 181 , 182 , 184 , 185 , 192 , 193 , 194 , 195 , 196 , 197 , 199 , 200 , 201 , 203 , 204 , 207 , 208 , 210 , 212 , 213 , 214 , 215 , 217 , 218 , 219 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 248 , 250 , 251 , 252 , 253 , 254 , 255 , 259 , 260 , 261 , 262 , 263 , 264 , 266 , 267 , 281 , 282 , 285 , 290 , 291 , 292 , 293 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 309 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 327 , 328 , 329 , 330 , 332 , 344 , 347 , 357 , 360 , 361 , 368 , 369 , 370 , 373 , 374 , 375 , 380 , 382 , 384 , 385 , 386 , 387 , 388 , 389 , 390 , 391 , 392 , 394 , 403 , 405 , 406 , 408 , 409 , 410 , 417 , 418 , 419 , 420 , 422 , 423 , 424 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 435 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 445 , 447 , 448 , 449 , 450 , 451 , 454 , 458 , 459 , 461 , 462 , 463 , 464 , 465 , 466 , 467 , 468 , 469 , 470 , 471 , 472 , 473 , 474 , 475 , 476 , 477 , 478 , 479 , 480 , 481 , 482 , 483 , 484 , 485 , 486 , 487 , 488 , 489 , 490 , 492 , 493 , 494 , 495 , 496 , 497 , 499 , 500 , 501 , 502 , 503 , 504 , 505 , 506 , 507 , 508 , 509 , 510 , 511 , 512 , 513 , 515 , 516 , 517 , 518 , 519 , 520 , 521 , 522 , 523 , 524 , 525 , 526 , 527 , 528 , 529 , 530 , 531 , 532 , 533 , 534 , 535 , 536 , 537 , 538 , 539 , 540 , 541 , 542 , 543 , 544 , 545 , 546 , 548 , 549 , 550 , 551 , 552 ) , phosphopeptide mapping ( 544 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 21 , 22 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 62 , 63 , 64 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 82 , 83 , 84 , 85 , 87 , 88 , 89 , 90 , 92 , 93 , 94 , 95 , 96 , 98 , 101 , 102 , 103 , 104 , 105 , 106 , 108 , 110 , 111 , 113 , 116 , 117 , 118 , 119 , 120 , 121 , 123 , 125 , 126 , 129 , 131 , 132 , 133 , 134 , 135 , 137 , 138 , 139 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 155 , 156 , 157 , 158 , 163 , 164 , 166 , 167 , 168 , 170 , 172 , 176 , 179 , 180 , 181 , 182 , 184 , 185 , 192 , 193 , 194 , 195 , 196 , 197 , 199 , 200 , 201 , 203 , 204 , 207 , 208 , 210 , 212 , 213 , 214 , 215 , 217 , 218 , 219 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 234 , 235 , 236 , 237 , 238 , 240 , 241 , 242 , 243 , 244 , 245 , 248 , 250 , 252 , 253 , 254 , 255 , 259 , 260 , 261 , 262 , 263 , 264 , 266 , 267 , 281 , 282 , 285 , 290 , 291 , 292 , 293 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 309 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 327 , 328 , 329 , 330 , 332 , 344 , 347 , 357 , 360 , 361 , 368 , 369 , 370 , 373 , 375 , 380 , 382 , 384 , 385 , 386 , 388 , 389 , 390 , 391 , 392 , 394 , 403 , 405 , 406 , 408 , 409 , 410 , 417 , 418 , 422 , 423 , 424 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 435 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 447 , 448 , 449 , 450 , 452 , 454 , 458 , 461 , 463 , 465 , 471 , 474 , 475 , 476 , 477 , 478 , 479 , 480 , 481 , 483 , 484 , 485 , 486 , 488 , 489 , 490 , 492 , 493 , 494 , 496 , 499 , 500 , 503 , 504 , 505 , 506 , 507 , 508 , 511 , 512 , 513 , 515 , 516 , 518 , 519 , 520 , 522 , 527 , 530 , 531 , 535 , 536 , 541 , 542 , 543 , 544 , 545 , 546 , 548 , 549 , 550 , 551 , 552 )
Disease tissue studied:	adrenal cancer ( 511 ) , pheochromocytoma ( 511 ) , breast cancer ( 24 , 53 , 63 , 148 , 176 , 430 , 452 , 543 ) , breast adenocarcinoma ( 63 ) , breast ductal carcinoma ( 63 ) , breast cancer, triple negative ( 24 , 63 ) , cervical cancer ( 516 ) , cervical adenocarcinoma ( 516 ) , colorectal cancer ( 233 , 486 ) , colorectal carcinoma ( 233 , 486 ) , endometrial cancer ( 50 ) , hypopharyngeal cancer ( 39 ) , leukemia ( 33 , 287 , 288 , 361 , 377 , 378 ) , acute myelogenous leukemia ( 33 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 361 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 33 ) , chronic myelogenous leukemia ( 33 , 377 , 378 ) , liver cancer ( 236 , 442 ) , lung cancer ( 37 , 46 , 48 , 88 , 224 , 354 , 355 , 356 , 358 , 359 , 362 , 363 , 364 , 365 , 366 , 367 , 410 , 433 ) , non-small cell lung cancer ( 37 , 46 , 48 , 88 , 224 , 354 , 355 , 356 , 362 , 363 , 364 , 365 , 366 , 367 ) , non-small cell lung adenocarcinoma ( 37 , 46 , 48 , 88 ) , lymphoma ( 33 , 300 , 521 ) , anaplastic large cell lymphoma ( 300 ) , B cell lymphoma ( 521 ) , neuroblastoma ( 215 , 484 , 515 ) , pancreatic cancer ( 78 , 261 , 370 ) , pancreatic carcinoma ( 78 , 261 , 370 ) , melanoma skin cancer ( 29 , 35 , 179 , 196 , 233 , 308 , 316 ) , cancer, squamous cell carcinoma ( 1 ) , testicular cancer ( 256 , 258 , 488 ) , diabetes mellitus ( 317 , 442 ) , type 2 diabetes ( 317 , 442 ) , Huntington's disease ( 151 ) , Turner-like syndrome ( 312 , 313 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 114 , 127 , 143 , 161 , 195 ) , 'B lymphocyte, precursor' ( 360 ) , 'brain, cerebellum' ( 42 , 465 , 542 ) , 'brain, cerebral cortex' ( 32 , 113 , 431 , 482 , 537 ) , 'brain, cerebrum' ( 465 , 542 ) , 'brain, embryonic' ( 411 , 413 ) , 'brain, embryonic' [BAG1 (mouse)] ( 460 ) , 'brain, frontal cortex' ( 104 ) , 'brain, hippocampus' ( 17 , 18 , 64 , 104 , 147 , 153 , 259 , 303 , 418 , 443 , 497 ) , 'brain, hippocampus' [DLG3 (mouse), homozygous knockout] ( 417 ) , 'brain, hippocampus, CA1 region' ( 104 ) , 'brain, hippocampus, dentate gyrus' ( 104 ) , 'brain, hypothalamus' ( 38 , 66 ) , 'brain, hypothalamus, suprachiasmatic nucleus' ( 470 ) , 'brain, nucleus accumbens' ( 104 ) , 'brain, striatum' ( 28 , 151 , 307 , 422 , 464 , 476 , 483 , 490 , 533 ) , 'brain, thalamus' ( 32 ) , 'epithelial, lung' [homozygous knockout] ( 235 ) , 'fat, brown' ( 232 ) , 'heart, ventricle' ( 70 ) , 'liver, fetal' ( 441 ) , 'muscle, skeletal' ( 233 , 290 , 357 , 405 , 489 ) , 'neuron, cortical' ( 100 ) , 'neuron, cortical'-brain ( 152 , 170 , 254 , 512 , 517 , 526 ) , 'neuron, cortical'-brain [NYAP2 (mouse), homozygous knockout] ( 185 ) , 'neuron, dorsal horn'-spinal cord ( 374 ) , 'neuron, hippocampal'-brain [neurogranin (mouse)] ( 530 ) , 'neuron, superior cervical ganglion' ( 329 ) , 'renal, podocyte' ( 243 ) , 'stem, embryonic' ( 265 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 357 ) , 'stem, mesenchymal' ( 383 ) , 293 (epithelial) ( 144 , 305 , 454 , 471 , 472 , 544 ) , 32D (myeloid) ( 219 , 508 , 549 ) , 3T3 (fibroblast) [CDC42 (human), transfection] ( 159 ) , 3T3 (fibroblast) [INSR (human)] ( 544 ) , 3T3 (fibroblast) [INSR (mouse), transfection] ( 302 ) , 3T3 (fibroblast) [KRas (human), transfection] ( 159 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 451 , 459 , 469 , 471 , 478 , 496 , 506 , 510 , 529 , 552 ) , 3T3 (fibroblast) [Src (human)] ( 433 ) , 3T3 (fibroblast) ( 108 , 158 , 159 , 182 , 225 , 291 , 302 , 382 , 435 , 439 , 452 , 463 , 485 , 499 , 516 , 519 , 536 , 550 , 551 ) , 3T3-L1 (fibroblast) ( 94 , 168 , 203 , 260 , 390 , 392 , 403 , 446 , 500 ) , 4T1 (breast cell) ( 24 , 148 , 543 ) , A549 (pulmonary) ( 37 , 48 , 88 ) , AB.1 (T lymphocyte) ( 240 ) , adipocyte-adipose tissue ( 3 , 541 ) , adipose tissue ( 14 , 233 , 357 ) , adipose tissue [DUSP6 (mouse), homozygous knockout] ( 146 ) , adrenal gland ( 233 ) , alphaT3-1 (pituitary cell) ( 155 ) , AML3080 ( 33 ) , AML3179 ( 33 ) , AML3220 ( 33 ) , artery ( 368 ) , B lymphocyte ( 110 , 188 , 251 , 360 ) , B lymphocyte-spleen ( 222 , 253 , 425 ) , B lymphocyte-spleen [PTEN (mouse), transgenic] ( 267 ) , B16 (melanocyte) ( 29 , 179 ) , B16F1 (melanocyte) ( 196 , 316 ) , B16F10 ( 35 , 119 ) , B6 ( 10 ) , BAC1.2F5 (macrophage) ( 532 ) , BaF3 ('B lymphocyte, precursor') [EGFR (human)] ( 433 ) , BaF3 ('B lymphocyte, precursor') [FLT3 (human)] ( 444 ) , BaF3 ('B lymphocyte, precursor') ( 1 , 85 , 163 , 250 , 262 , 302 , 315 , 361 , 377 , 378 , 391 , 428 , 461 , 462 , 508 , 520 ) , BALB/MK (keratinocyte) ( 548 ) , BEAS-2B (epithelial) ( 88 ) , beta-pancreas ( 261 , 328 ) , beta-pancreas [INSR (mouse), transgenic] ( 245 ) , bladder ( 373 ) , BMMC (mast) ( 150 , 229 , 314 , 545 ) , bone marrow ( 10 , 33 , 95 , 118 , 428 ) , brain ( 23 , 66 , 92 , 174 , 177 , 178 , 199 , 232 , 247 , 286 , 372 , 412 , 414 , 523 ) , brain [DARPP-32 (mouse), homozygous knockout] ( 479 ) , brain [NYAP2 (mouse), homozygous knockout] ( 185 ) , breast cell ( 176 ) , breast cell-breast ( 148 ) , BT-474 (breast cell) ( 53 ) , BT-549 (breast cell) ( 24 ) , BV2 (microglia) ( 68 ) , C2C12 (myoblast) ( 69 , 120 , 474 , 503 ) , C2C12-D (muscle cell) ( 415 , 416 ) , C3H10T1/2 (fibroblast) ( 341 , 342 , 343 , 427 , 501 ) , C666-1 ( 39 ) , CCE ( 481 ) , CD4+ (T lymphocyte) ( 49 , 59 , 62 , 87 , 211 ) , CD8+ (T lymphocyte) ( 58 ) , CHO (fibroblast) ( 116 ) , CMT-93 (intestinal) ( 486 ) , CNE1 ( 39 ) , COLO-205 (intestinal) ( 233 ) , colon ( 67 , 238 ) , COS (fibroblast) ( 126 , 163 , 302 , 437 , 485 , 499 , 518 ) , CTL-EN (T lymphocyte) ( 375 ) , D2A1 ( 41 ) , D4M ( 21 ) , dendritic cell ( 382 ) , dendritic cell [MAPKAPK2 (mouse), homozygous knockout] ( 382 ) , dendritic cell [MSK1 (mouse), homozygous knockout] ( 382 ) , E14 ('neuron, hippocampal') ( 172 ) , E14tg2a ('stem, embryonic') ( 481 ) , embryo ( 178 , 441 ) , embryonic ( 164 ) , endometrium ( 50 ) , endothelial ( 26 , 321 ) , endothelial-pulmonary artery ( 248 ) , endothelial-vein ( 248 ) , epithelial ( 67 , 495 ) , epithelial-'kidney, tubule' ( 48 , 386 ) , epithelial-lens ( 406 ) , erythroblast ( 361 ) , erythroid ( 10 , 80 ) , ES (stem) ( 144 , 448 , 450 ) , F9 (testicular) ( 256 , 488 ) , FaDu (squamous) ( 1 ) , Fao (hepatic) ( 236 , 442 ) , FDCP-1 (myeloid) ( 30 , 244 ) , fibroblast-embryo [BAG1 (mouse)] ( 460 ) , fibroblast-heart ( 48 ) , fibroblast-lung ( 93 , 298 ) , gastrointestinal tract ( 20 ) , GD25 (fibroblast) ( 505 ) , GL261 (glial) ( 263 ) , GT1-7 (neuron) ( 384 , 445 , 509 ) , H157 ( 37 ) , HaCaT (keratinocyte) ( 385 ) , HBMEC (endothelial) ( 22 ) , HCC1937 (breast cell) ( 63 ) , HCC38 (breast cell) ( 63 ) , heart ( 14 , 31 , 77 , 79 , 99 , 162 , 192 , 232 , 305 , 310 , 311 , 312 , 313 , 357 , 388 , 404 , 407 , 429 ) , HEK293T (epithelial) ( 116 , 170 , 184 , 197 ) , HEL (erythroid) ( 361 ) , HeLa (cervical) ( 218 ) , HeLa S3 (cervical) ( 516 ) , hematopoietic progenitor-bone marrow ( 80 ) , Hepa 1-6 (epithelial) ( 83 ) , hepatocyte ( 48 , 54 , 83 , 450 ) , HepG2 (hepatic) ( 442 ) , HMV-II ( 47 ) , HT-22 (neuron) ( 517 ) , HT-4 (neuron) ( 517 ) , HTR8/SVneo (trophoblast) ( 56 ) , HUVEC (endothelial) ( 217 , 321 ) , IBE (endothelial) ( 522 ) , ileum ( 67 ) , intestine ( 81 ) , J774 (macrophage) ( 507 , 527 ) , JB (epithelial) ( 477 , 539 ) , JB-6 (lymphocyte) ( 300 ) , JB6 RT101 (epidermal) ( 449 ) , JS1 ( 96 ) , Jurkat (T lymphocyte) ( 318 ) , K-1735 (melanocyte) ( 233 ) , K562 (erythroid) ( 33 ) , keratinocyte ( 193 ) , keratinocyte-skin [IGF1 (mouse)] ( 454 ) , kidney ( 102 , 232 , 233 ) , Leydig TM3 (Leydig) ( 82 ) , liver ( 12 , 33 , 48 , 98 , 103 , 109 , 160 , 171 , 178 , 210 , 232 , 233 , 236 , 301 , 344 , 357 , 399 , 400 , 401 , 402 , 421 , 442 , 534 ) , liver [Akt2 (mouse), homozygous knockout] ( 395 , 396 , 397 , 398 ) , LLC-PK1 (renal) ( 494 ) , LU-NB-1 ( 60 ) , lung ( 11 , 65 , 88 , 124 , 232 , 233 , 321 , 331 , 354 , 355 , 356 , 410 ) , lung [EGFR (mouse), transgenic] ( 358 ) , lung [HRas (mouse), transgenic] ( 359 ) , lung [p27Kip1 (mouse), genetic knockin] ( 204 ) , lymphocyte ( 15 , 16 , 25 , 51 , 62 ) , lymphocyte-spleen ( 59 , 71 ) , macrophage ( 437 ) , macrophage-blood ( 472 ) , macrophage-bone marrow ( 5 , 8 , 76 , 84 , 111 , 129 , 167 , 246 , 419 , 424 , 466 ) , macrophage-bone marrow [Cot (mouse)] ( 380 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 246 ) , macrophage-bone marrow [NFkB-p105 (human)] ( 380 ) , macrophage-peritoneum ( 75 , 106 , 121 , 169 , 214 , 546 ) , mammary gland ( 82 ) , mast-bone marrow ( 36 , 125 , 241 , 304 , 376 , 425 , 438 , 513 ) , mast-bone marrow [PTPRA (mouse), homozygous knockout] ( 320 ) , mast-bone marrow [SHP-2 (mouse), homozygous knockout] ( 281 ) , MC/9 (mast) ( 508 ) , MC3T3 (preosteoblast) ( 145 ) , MC3T3-E1 (preosteoblast) ( 117 ) , MCF-7 (breast cell) ( 452 ) , MCP-5 (mast) ( 376 ) , MCT cells (epithelial) ( 317 ) , MDA-MB-231 (breast cell) ( 24 ) , MDA-MB-468 (breast cell) ( 63 ) , MDPC-23 (dental pulp cells) ( 166 ) , MEF (fibroblast) [HRas (mouse), HRas V12] ( 295 ) , MEF (fibroblast) [IGF1R (mouse)] ( 420 , 467 , 473 , 487 ) , MEF (fibroblast) [LKB1 (mouse)] ( 493 ) , MEF (fibroblast) [MSK1 (mouse), homozygous knockout, msk2] ( 535 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 205 ) , MEF (fibroblast) [PDGFRA (mouse), genetic knockin] ( 299 ) , MEF (fibroblast) [PKR (mouse), homozygous knockout] ( 227 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 326 ) , MEF (fibroblast) [RAF1 (mouse), homozygous knockout] ( 327 ) , MEF (fibroblast) [Raptor (mouse), knockdown] ( 165 ) , MEF (fibroblast) [RICTOR (mouse), knockdown] ( 165 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 206 ) , MEF (fibroblast) ( 45 , 89 , 105 , 121 , 157 , 165 , 181 , 184 , 196 , 197 , 218 , 222 , 234 , 285 , 294 , 296 , 326 , 333 , 347 , 369 , 385 , 389 , 394 , 408 , 429 , 434 , 437 , 439 , 440 , 480 , 504 , 539 , 540 ) , Mel-Ab (melanocyte) ( 223 ) , mesangial ( 502 ) , Met-1 (breast cell) ( 176 ) , microglia ( 9 , 423 ) , microvessel endothelial-lung [GIT1 (mouse), homozygous knockout] ( 156 ) , mIMCD-3 (epithelial) ( 531 ) , MIN6 (pancreatic) ( 78 , 261 , 370 ) , MLE (epithelial) ( 468 ) , mLEC (epithelial) ( 213 ) , MLO-Y4 (osteoblast) ( 123 ) , MLP-29 ( 282 ) , MN9D ('neuron, mesencephalic') ( 231 ) , MS1 (endothelial) ( 474 ) , muscle ( 319 ) , MV4-11 (macrophage) ( 33 ) , myeloid ( 424 ) , myeloid-bone marrow ( 361 ) , myocyte ( 77 ) , myocyte-heart ( 2 , 26 , 90 , 142 , 305 , 429 , 458 ) , N18 (neuron) ( 515 ) , NB41A3 ( 132 ) , NCI-H1792 (pulmonary) ( 48 ) , NCI-H23 (pulmonary) ( 46 ) , Neuro-2a (neuron) ( 215 ) , neuron ( 6 ) , neuron-'brain, cerebral cortex' ( 212 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 115 ) , neutrophil ( 73 ) , NHDF (fibroblast) ( 157 ) , NMuMG (epithelial) ( 543 ) , NSCLC (pulmonary) ( 224 ) , oocyte ( 97 ) , osteoclast ( 424 ) , ovary ( 200 ) , P19 (testicular) ( 258 ) , pancreas ( 34 , 232 , 233 ) , pancreatic ( 4 ) , pancreatic islet ( 328 ) , PC-12 (chromaffin) ( 511 ) , platelet ( 13 , 52 ) , platelet-blood ( 239 ) , preosteoclast ( 447 ) , prostate ( 43 , 44 , 180 , 344 ) , R1 ('stem, embryonic') ( 515 ) , R22 ('muscle, smooth') ( 369 ) , RAW 264 (macrophage) ( 472 , 475 ) , RAW 264.7 (macrophage) ( 7 , 57 , 74 , 75 , 101 , 140 , 226 , 287 , 288 , 293 ) , REF52 (fibroblast) ( 518 ) , SCC16-5 (fibroblast) ( 538 ) , skin ( 230 , 344 , 501 ) , skin [Fyn (mouse), transgenic] ( 264 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 308 ) , SN56 (neuron) ( 484 ) , spleen ( 55 , 232 , 233 , 276 , 280 , 284 ) , STC-1 (endocrine) ( 525 ) , stromal ( 208 ) , Swiss 3T3 (fibroblast) ( 492 ) , SYF (fibroblast) [Src iso1 (mouse), transfection] ( 175 ) , SYF (fibroblast) ( 242 , 369 , 439 ) , T lymphocyte ( 87 , 309 , 330 ) , T lymphocyte [FOXO1A (mouse), transgenic] ( 207 ) , T lymphocyte [PELI1 (mouse), homozygous knockout] ( 194 ) , T lymphocyte-blood ( 211 , 306 , 387 ) , T lymphocyte-lymph node ( 266 , 409 , 425 ) , T lymphocyte-lymph node [PRKD1 (mouse), genetic knockin] ( 237 ) , T lymphocyte-lymph node [PRKD2 (mouse), genetic knockin] ( 237 ) , T lymphocyte-spleen ( 220 , 228 , 432 ) , T lymphocyte-spleen [LAT (mouse), transgenic] ( 255 ) , T lymphocyte-thymus ( 211 ) , T47D (breast cell) ( 430 ) , testis ( 232 , 275 , 278 , 283 ) , thoracic aorta ( 19 ) , thymocyte ( 27 , 62 , 89 , 131 , 436 ) , thymocyte [CBL (mouse), homozygous knockout] ( 252 ) , thymus ( 277 , 279 ) , thyroid ( 233 ) , thyroid [BRAF (human), genetic knockin] ( 201 ) , U-937 (myeloid) ( 33 ) , uterus ( 133 ) , vascular smooth muscle cell ('muscle, smooth') ( 332 , 369 ) , WEHI-231 (B lymphocyte) ( 521 ) , WT-1 ( 40 ) , YUMM 1.7 (melanocyte) ( 21 ) , YUMM 3.3 (melanocyte) ( 21 ) , YUMM 4.1 (melanocyte) ( 21 )

Upstream Regulation
Regulatory protein:	ADAMTSL3 (human) ( 18 ) , ADRA1A (human) ( 31 ) , ADRB1 (mouse) ( 162 ) , AIF1 (mouse) ( 135 ) , Akt1 (mouse) ( 545 ) , ALK (human) ( 250 ) , ANXA5 (human) ( 84 ) , ARAF (human) ( 370 ) , ARAF (mouse) ( 370 ) , ARHGEF7 (mouse) ( 439 ) , ARRB1 (mouse) ( 261 ) , ATG7 (human) ( 22 ) , BAG1 (mouse) ( 460 ) , Bcl-10 (mouse) ( 425 ) , BCR-ABL1 (human) ( 433 ) , BDNF (mouse) ( 131 ) , BRAF (human) ( 21 , 329 ) , BRAF (mouse) ( 182 ) , BRAF iso1 (mouse) ( 487 ) , Btk (mouse) ( 314 ) , CAMK2D (human) ( 384 ) , CAPNS1 (mouse) ( 77 ) , CARD11 (mouse) ( 425 ) , CARD9 (mouse) ( 136 ) , Cas-L (human) ( 65 ) , CBL (mouse) ( 436 ) , Cbl-b (human) ( 62 ) , Cbl-b (mouse) ( 436 ) , CD151 (mouse) ( 125 ) , CD44 (mouse) ( 437 ) , CD74 (mouse) ( 437 ) , CDC42 (mouse) ( 159 ) , CDC42 iso1 (mouse) ( 439 ) , CDK5R1 (mouse) ( 476 ) , CDKL5 (human) ( 17 ) , CNR1 (human) ( 97 ) , CNR2 (human) ( 97 ) , Cot (human) ( 197 ) , Cot (mouse) ( 467 ) , CTH (human) ( 39 ) , CTNNB1 (mouse) ( 81 ) , CXCL11 (human) ( 43 ) , dectin-1 (mouse) ( 136 ) , DENR (human) ( 7 ) , DGCR2 (mouse) ( 100 ) , DLG3 (mouse) ( 417 ) , DOK3 (mouse) ( 15 , 167 ) , DUSP6 (mouse) ( 146 , 236 ) , EAR-2 (mouse) ( 330 ) , EGFR (mouse) ( 369 ) , ERG (mouse) ( 180 ) , ERK2 (mouse) ( 449 ) , FADD (mouse) ( 141 ) , FAK iso2 (mouse) ( 480 , 499 ) , FCER1A (mouse) ( 376 ) , Fes (mouse) ( 304 , 532 ) , FGFR1 (human) ( 391 ) , FGFR2 (mouse) ( 72 ) , FGFR3 (human) ( 105 ) , FMR1 (mouse) ( 113 , 443 ) , FOXO1A (mouse) ( 236 ) , FOXP1 (mouse) ( 207 ) , G-alpha i2 (human) ( 197 ) , G-beta 1 (mouse) ( 197 ) , G-CSF (mouse) ( 95 ) , GAB2 (mouse) ( 118 ) , GCH1 (mouse) ( 26 ) , GIPC1 (mouse) ( 248 ) , GIT1 (human) ( 156 ) , GLRX1 (mouse) ( 406 ) , GPS2 (mouse) ( 110 ) , GRB10 (human) ( 163 ) , GRB10 (mouse) ( 130 ) , HePTP (mouse) ( 306 ) , HLAA (human) ( 25 ) , HRas (human) ( 83 ) , HRas (mouse) ( 181 , 224 , 544 ) , ICMT (mouse) ( 504 ) , IFNAR1 (mouse) ( 10 ) , IGBP1 (mouse) ( 40 ) , IGF1R (mouse) ( 491 ) , IL17RD (mouse) ( 506 ) , IL4R (mouse) ( 148 ) , INDO (mouse) ( 35 ) , IRF3 (mouse) ( 36 ) , IRS1 (mouse) ( 541 ) , ITGA9 (human) ( 428 ) , JAK2 (human) ( 361 , 520 ) , JAK3 (human) ( 85 ) , JNK2 (mouse) ( 129 , 181 , 216 ) , Kit (human) ( 30 ) , Kit (mouse) ( 244 ) , Klotho (mouse) ( 147 ) , KRas (human) ( 67 ) , KRas (mouse) ( 159 , 180 , 434 , 548 ) , KSR (human) ( 234 ) , LAB (mouse) ( 432 ) , LAT (mouse) ( 255 ) , Lck (human) ( 71 ) , LGR5 (human) ( 44 ) , LKB1 (human) ( 48 ) , MAPKAPK2 (mouse) ( 382 ) , MAPKAPK3 (mouse) ( 382 ) , MAVS (mouse) ( 36 ) , MDA5 (mouse) ( 36 ) , MEK1 (mouse) ( 213 , 518 ) , MEKK1 (mouse) ( 144 ) , mGluR5 (mouse) ( 374 ) , MRas (human) ( 508 ) , MSK1 (human) ( 535 ) , MSK1 (mouse) ( 535 ) , MSK2 (mouse) ( 535 ) , MST1 (mouse) ( 309 ) , mTOR (human) ( 61 ) , MUC4 (human) ( 34 ) , neurogranin (mouse) ( 530 ) , NPC1 (mouse) ( 465 , 542 ) , NPM1 (human) ( 250 ) , NYAP2 (mouse) ( 185 ) , P2Y2 (human) ( 19 ) , PAG (rat) ( 347 ) , PAK1 (human) ( 518 ) , PD-L1 (human) ( 58 ) , PDGFRA (mouse) ( 299 ) , PDK1 (mouse) ( 328 , 357 , 450 ) , PDYN (mouse) ( 32 ) , PELI1 (mouse) ( 194 ) , PGLYRP1 (human) ( 9 ) , PHLPP (mouse) ( 211 ) , PKCA (mouse) ( 321 ) , PKCG (human) ( 42 ) , PKCT (mouse) ( 368 ) , PKDCC (human) ( 52 ) , PKM iso2 (human) ( 70 ) , Plectin-1 (human) ( 47 ) , PPP1CC (human) ( 332 ) , PRKD1 (mouse) ( 492 ) , Prl2a1 (mouse) ( 33 ) , PRMT5 (human) ( 196 ) , PRMT5 (mouse) ( 196 ) , PRMT5 (rat) ( 196 ) , PRMT6 (mouse) ( 98 ) , PTEN (human) ( 6 ) , PTEN (mouse) ( 137 ) , PTP1B (mouse) ( 248 ) , PTPRB (mouse) ( 248 ) , PTPRH (human) ( 46 ) , PTPRJ (mouse) ( 248 ) , PTPRM (mouse) ( 248 ) , RAB11A (mouse) ( 248 ) , Rab7 (mouse) ( 248 ) , RAC1 (mouse) ( 518 ) , RAF1 (human) ( 196 ) , RAF1 (mouse) ( 518 ) , RAIG1 (mouse) ( 235 ) , Raptor (mouse) ( 319 ) , RASAL2 (human) ( 63 ) , Ret (human) ( 329 , 435 ) , RHOC (mouse) ( 179 ) , RIGI (human) ( 36 ) , ROCK1 (mouse) ( 290 ) , RSK2 (human) ( 82 ) , RSK2 (mouse) ( 385 ) , SENP3 (mouse) ( 101 ) , SGPL1 (mouse) ( 197 ) , SH3BP2 (mouse) ( 424 ) , SHC1 iso2 (human) ( 420 ) , SHP-2 (human) ( 210 ) , SHP-2 (mouse) ( 281 , 529 ) , Sin1 (mouse) ( 89 ) , SIRT6 (mouse) ( 102 ) , SOCS1 (mouse) ( 499 ) , SOCS3 (mouse) ( 499 ) , Src (human) ( 433 ) , Src iso1 (mouse) ( 179 ) , Syk (mouse) ( 360 ) , syndecan-4 (mouse) ( 321 ) , TAK1 (mouse) ( 429 ) , TBK1 (mouse) ( 434 ) , TCL1A (human) ( 251 ) , Tel (human) ( 520 ) , TFEB (human) ( 21 ) , TH (human) ( 23 ) , THEMIS (human) ( 49 ) , TLR4 (human) ( 76 ) , TNFRSF18 (human) ( 59 ) , TRAF1 (human) ( 111 ) , TRAF3 (human) ( 59 ) , TRIM40 (mouse) ( 106 ) , TSC2 (mouse) ( 245 , 440 ) , UCP2 (mouse) ( 419 ) , VAV1 (human) ( 55 ) , VEGF (human) ( 233 ) , VEGFR3 (mouse) ( 213 ) , Vinculin (mouse) ( 488 ) , ZAP70 (human) ( 62 ) , ZAP70 (mouse) ( 360 )
Putative in vivo kinases:	MEK1 (mouse) ( 66 , 452 )
Kinases, in vitro:	MEK1 (mouse) ( 518 , 553 ) , MEK1 (rat) ( 249 )
Putative upstream phosphatases:	DUSP1 (human) ( 21 ) , PPP2CA (mouse) ( 532 ) , STS-1 (mouse) ( 239 )
Phosphatases, in vitro:	STS-1 (mouse) ( 239 )
Treatments:	15d-PGJ2 ( 486 ) , 17-beta-estradiol ( 133 ) , 1Na-PP1 ( 254 ) , 2',5'-oligoadenylate ( 5 ) , 22-hydroxycholesterol ( 468 ) , 5'-methylthioadenosine ( 196 ) , 6-OHDA ( 231 ) , 7, 8-Dihydroxyflavone ( 69 ) , 8-(3-chlorostyryl) caffeine ( 388 ) , 9d ( 303 ) , A23187 ( 546 ) , acadesine ( 493 ) , ADP ( 52 ) , adriamycin ( 90 , 227 ) , aflibercept ( 233 ) , AG1024 ( 78 ) , AG1478 ( 56 , 68 , 193 , 243 , 289 ) , AG490 ( 144 , 507 ) , AGEs ( 121 ) , Akt-I-1 ( 370 ) , Akt-I-1,2 ( 58 ) , Akt_activator_compound_11 ( 225 ) , Akt_inhibitor_VIII ( 302 ) , alloxazine ( 388 ) , alpha-IgM ( 110 ) , alpha-lipoic_acid ( 215 ) , amino_acid_starvation ( 89 , 302 ) , amino_acids ( 184 , 302 ) , amphoterin ( 515 ) , angiopoietin-1 ( 474 ) , angiopoietin-2 ( 474 ) , anisomycin ( 382 , 535 , 546 ) , antibody ( 1 , 15 , 16 , 25 , 48 , 51 , 58 , 62 , 71 , 90 , 99 , 207 , 228 , 240 , 252 , 253 , 266 , 267 , 281 , 309 , 318 , 327 , 360 , 387 , 409 , 432 , 436 , 453 , 474 ) , antichymotrypsin ( 431 ) , antigenic stimulation ( 36 , 241 ) , antitrypsin ( 431 ) , aphidicolin ( 485 ) , apigenin ( 507 ) , apomorphine ( 464 ) , artemin ( 132 ) , AT-403 ( 28 ) , atorvastatin ( 388 ) , ATP ( 19 ) , AZD4547 ( 1 ) , AZD8055 ( 157 ) , bacterial infection ( 7 , 75 , 238 ) , BAPTA-AM ( 522 , 525 , 536 ) , Bay61-3606 ( 241 ) , BCI ( 21 ) , BDNF ( 69 , 170 , 254 , 551 ) , benzo(a)pyrene ( 410 ) , beta-amyloid_40 ( 484 ) , BFD-22 ( 119 ) , BI-D1870 ( 48 , 121 , 266 , 382 ) , bicuculline ( 212 ) , BIRA766 ( 241 ) , BIRB-0796 ( 382 ) , bisindolylmaleimide ( 515 ) , black_tea_polyphenols ( 230 ) , bleomycin ( 124 ) , BMP7 ( 2 ) , bombesin ( 289 , 492 ) , bradykinin ( 134 ) , BRL37344 ( 478 ) , C6-ceramide ( 58 ) , caffeic_acid ( 300 ) , caffeine ( 422 ) , calorie_restriction ( 344 ) , calpain inhibitor-III ( 77 ) , calphostin_C ( 515 ) , calyculin_A ( 548 ) , cAMP_analog ( 510 , 522 ) , CCG-203920 ( 28 ) , CCL19 ( 58 ) , CCL21 ( 58 ) , CCX771 ( 43 ) , cell_adhesion ( 306 ) , cell_detachment ( 488 ) , CGP77675 ( 494 ) , CGS_21680 ( 422 ) , chelerythrine ( 515 ) , chlorogenic_acid ( 300 ) , chronic mild stress ( 32 ) , chronic social defeat stress ( 104 ) , ciclopirox_olamine ( 213 ) , cigarette_smoke ( 57 ) , cisplatin ( 102 ) , clinostat ( 117 ) , cocaine ( 476 , 479 ) , cold_water_stress ( 418 ) , colforsin ( 234 , 422 , 471 , 473 , 522 , 530 ) , Collagen related peptide ( 13 ) , compound 21 ( 14 ) , compound_56 ( 289 ) , ConA ( 301 ) , convulxin ( 239 ) , CRM197 ( 88 ) , curcumin ( 226 ) , curdlan ( 136 ) , CXCL12 ( 381 , 521 ) , cyclic_stretch ( 243 ) , cycloheximide ( 292 ) , cytochalasin_D ( 494 ) , D-Can peptide ( 43 ) , D-galactosamine ( 96 ) , dactolisib ( 176 ) , dasatinib ( 30 ) , DDA ( 306 ) , depolarization ( 483 ) , development ( 82 ) , dexamethasone ( 390 , 427 ) , DHPG ( 374 , 443 ) , diet ( 147 ) , differentiation ( 166 , 224 ) , DMNQ ( 332 ) , DNP ( 545 ) , DNP-HSA ( 314 ) , DPCPX ( 388 ) , dronabinol ( 97 , 152 ) , ebastine ( 24 ) , EDTA ( 474 ) , EGF ( 56 , 61 , 134 , 144 , 193 , 196 , 216 , 234 , 235 , 291 , 385 , 386 , 408 , 426 , 427 , 439 , 471 , 478 , 485 , 487 , 492 , 504 , 506 , 518 , 528 , 529 , 531 , 535 , 540 , 543 , 544 , 548 , 552 ) , EGTA ( 292 ) , entospletinib ( 76 ) , Epo ( 10 , 80 , 262 , 361 , 457 ) , epoxomicin ( 282 ) , estradiol ( 484 , 537 ) , ethanol ( 523 , 534 ) , ether ( 418 ) , etoposide ( 157 ) , extract ( 94 ) , faslodex ( 69 , 430 , 484 ) , fedratinib ( 361 ) , FGF1 ( 1 , 72 , 108 , 196 , 517 ) , FGF2 ( 41 , 196 , 321 , 506 , 511 , 522 ) , fibronectin ( 471 , 518 ) , fingolimod ( 151 ) , fisetin ( 153 ) , FL ( 444 ) , fluid_shear_stress ( 123 ) , food deprivation ( 418 ) , FR180204 ( 58 ) , fructose ( 48 ) , G-CSF ( 428 ) , GDNF ( 329 ) , gefitinib ( 63 , 433 ) , gelatin ( 515 ) , GF109203X ( 197 , 289 , 522 ) , GH ( 451 ) , GLP-1 ( 261 ) , glucose ( 243 , 245 , 317 , 498 , 502 ) , glucose_starvation ( 89 ) , GM-CSF ( 375 ) , GNE-149 ( 6 ) , GnRH ( 155 , 384 ) , Go_6976 ( 515 ) , gp120 ( 93 ) , GSK2636771 ( 3 ) , guanosine ( 423 ) , Guttiferone K ( 75 ) , GW4869 ( 143 ) , H-89 ( 234 , 261 , 306 , 430 , 471 , 515 ) , H2O2 ( 240 , 243 , 420 , 463 ) , heme ( 76 ) , heparin sodium ( 1 , 447 ) , heparinase ( 1 ) , herstatin ( 528 ) , HGF ( 196 ) , high-fat diet ( 64 , 344 ) , honokiol ( 203 ) , hydroxyurea ( 452 ) , hypertonic_buffer ( 459 ) , hypoxia ( 260 , 526 ) , IBMX ( 234 , 390 , 427 , 471 , 473 ) , IDRX-42 ( 20 ) , IFN-alpha ( 10 , 285 ) , IFN-gamma ( 84 , 423 , 507 , 538 ) , IgE ( 545 ) , IGF-1 ( 142 , 298 , 455 , 478 , 491 , 498 , 548 , 549 ) , IGF-2 ( 455 ) , IgG ( 466 ) , IL-11 ( 48 ) , IL-18 ( 126 ) , IL-1b ( 467 ) , IL-2 ( 16 ) , IL-3 ( 250 , 361 , 461 , 508 , 520 , 549 ) , IL-33 ( 80 , 140 ) , IL-4 ( 148 , 508 ) , IL-6 ( 48 , 210 ) , IL-9 ( 508 ) , imatinib ( 250 ) , insulin ( 14 , 38 , 40 , 54 , 83 , 120 , 161 , 184 , 195 , 203 , 236 , 245 , 290 , 302 , 317 , 340 , 357 , 368 , 390 , 392 , 445 , 446 , 455 , 469 , 478 , 489 , 500 , 536 , 541 , 544 ) , ionizing_radiation ( 157 ) , ionomycin ( 194 , 240 , 425 , 548 ) , ischemia/reperfusion ( 92 , 456 ) , isoorientin ( 74 ) , isoproterenol ( 478 , 510 ) , iturelix ( 384 ) , JB-1 ( 147 ) , K252a ( 69 ) , kaempferol ( 385 ) , kainic_acid ( 497 ) , ketamine ( 104 ) , KN-93 ( 384 ) , KT5823 ( 212 ) , L-744,832 ( 548 ) , L-DOPA ( 23 ) , L-glutamine_withdrawal ( 89 ) , L-NAME ( 212 ) , laminin-1 ( 515 ) , leflunomide ( 300 ) , leptin ( 527 ) , leucine ( 196 ) , levamfetamine ( 479 ) , LG268 ( 489 ) , licochalcone_A ( 293 ) , licochalcone_B ( 293 ) , licochalcone_C ( 293 ) , licochalcone_D ( 293 ) , LIF ( 448 , 481 ) , LIF withdrawal ( 122 ) , light ( 66 , 128 , 470 ) , lithium ( 74 ) , lonafarnib ( 141 ) , long-term_potentiation ( 259 ) , low_glucose ( 78 , 243 ) , LPA ( 193 , 209 , 478 , 487 , 540 ) , LPS ( 74 , 84 , 96 , 106 , 129 , 167 , 210 , 214 , 226 , 246 , 293 , 382 , 419 , 466 , 472 , 475 , 486 , 534 ) , LTV-1 ( 59 ) , LY294002 ( 56 , 120 , 148 , 266 , 302 , 318 , 441 , 457 , 481 , 517 , 522 , 544 ) , M-CSF ( 393 , 424 , 519 , 532 ) , M3814 ( 30 ) , Me6TREN ( 81 ) , melatonin ( 117 ) , metamfetamine ( 231 ) , methotrexate ( 504 ) , methyl-beta-cyclodextrin ( 427 ) , MG132 ( 282 , 475 ) , Microgravity ( 77 ) , midazolam ( 458 ) , MIF ( 437 ) , miR-15a/miR-16 ( 51 ) , miR-181a ( 409 ) , MitoTEMPO ( 76 ) , MK801 ( 212 ) , MMS ( 440 ) , MnTBAP ( 212 ) , morphine ( 68 ) , MPTP ( 490 ) , MRS-1523 ( 388 ) , MRTX1133 ( 11 ) , MSH ( 196 ) , muramyl_dipeptide ( 208 ) , myocardial infarction ( 70 ) , N-arachidonoyl-L-serine ( 199 ) , NAC ( 76 , 215 ) , nicotine ( 503 ) , nifedipine ( 261 ) , NMDA ( 417 ) , nocodazole ( 485 ) , nomifensine ( 490 ) , NP68 ( 266 ) , NSC697923 ( 144 ) , NTCU ( 410 ) , NVP-BKM120 ( 176 ) , ODQ ( 212 ) , OH-BBN ( 373 ) , okadaic_acid ( 433 , 546 ) , oophorectomy ( 82 ) , orantinib ( 435 ) , Oridonin ( 96 ) , OVA ( 237 ) , PACAP ( 470 ) , PAG ( 39 ) , palmitate ( 48 , 368 , 389 ) , Pam3CSK4 ( 382 ) , PAR1-activating_peptide ( 52 , 513 ) , PD0325901 ( 57 , 63 , 141 , 200 ) , PD169316 ( 539 ) , PD184352 ( 133 , 382 , 535 ) , PD90059 ( 430 ) , PD98059 ( 19 , 77 , 120 , 121 , 155 , 195 , 212 , 215 , 238 , 321 , 370 , 461 , 468 , 478 , 484 , 486 , 507 , 511 , 514 , 516 , 517 , 522 , 524 , 527 , 539 , 544 , 548 , 549 ) , PDGF ( 41 , 299 , 403 , 406 , 496 , 506 , 540 ) , peptones ( 525 ) , PF-04691502 ( 200 ) , PF562271 ( 78 ) , PGE2 ( 123 , 379 ) , phorbol_ester ( 16 , 89 , 194 , 196 , 230 , 292 , 382 , 425 , 451 , 487 , 494 , 522 , 530 , 535 , 540 , 546 , 548 ) , pilocarpine ( 497 ) , PKC-theta_pseudosubstrate ( 368 ) , plerixafor ( 43 , 93 ) , PLX4720 ( 21 ) , pomegranate_wine ( 410 ) , PP1 ( 155 , 496 , 544 ) , PP2 ( 300 , 318 , 427 , 437 , 491 , 496 , 522 , 537 ) , PRLi ( 33 ) , progestin_R5020 ( 430 ) , protozoan infection ( 79 ) , PTX ( 197 ) , quercetin 3-O-(6"-O-E-caffeoyl)—D-glucopyranoside ( 29 ) , quinpirole ( 512 ) , R406 ( 9 ) , racepinefrine ( 405 , 510 ) , raclopride ( 23 ) , RAD001 ( 58 ) , Raf1_kinase_inhibitor_I ( 370 ) , RANKL ( 424 ) , rapamycin ( 99 , 133 , 138 , 142 , 245 , 266 , 302 , 450 , 514 , 548 ) , reelin ( 100 ) , restraint stress ( 32 , 173 ) , resveratrol ( 230 ) , retinoic_acid ( 468 , 515 ) , RGD ( 474 ) , RGE ( 474 ) , rigosertib ( 60 ) , RO4987655 ( 182 ) , rosiglitazone ( 203 , 489 ) , rottlerin ( 420 ) , S107 ( 173 ) , saracatinib ( 78 ) , SB202190 ( 426 , 539 , 546 , 548 ) , SB203580 ( 77 , 292 , 382 , 494 , 535 ) , SCF ( 315 , 320 , 438 , 513 ) , SCH772984 ( 9 ) , SCH_23390 ( 23 ) , seliciclib ( 483 ) , semaxanib ( 435 ) , serum ( 89 , 292 , 327 , 450 , 463 , 487 , 506 , 540 , 548 ) , serum_starvation ( 89 ) , serum_withdrawal ( 516 ) , SF1670 ( 59 ) , silibinin ( 373 ) , silymarin ( 373 ) , Sinomenium acutum ( 13 ) , siRNA ( 385 , 392 , 439 ) , SKF38393 ( 28 , 512 ) , SKF81297 ( 307 ) , SKF82958 ( 497 ) , SL0101 ( 382 ) , SL327 ( 464 ) , SMI11293 ( 254 ) , sorbitol ( 552 ) , SP600125 ( 491 ) , sphingomyelin ( 143 ) , sphingosine_1-phosphate ( 137 , 223 ) , SPT ( 388 ) , staurosporine ( 420 ) , streptozotocin ( 442 ) , SU5402 ( 441 ) , SU6656 ( 433 ) , sunitinib ( 435 ) , tail suspension test ( 77 ) , TAK1_inhibitor ( 144 ) , TCAP-1 ( 172 ) , TCDD ( 427 ) , TDZD-8 ( 263 ) , TGF-alpha ( 528 ) , TGF-beta ( 48 , 144 , 166 , 201 , 369 , 533 , 543 ) , Theophylline ( 388 ) , thrombin ( 197 , 458 , 513 ) , thrombospondin ( 480 ) , TNF ( 195 , 382 , 394 , 423 , 467 , 547 ) , TNO155 ( 41 ) , topotecan ( 157 ) , Torin1 ( 89 ) , Trametinib ( 45 ) , trastuzumab ( 53 ) , triciribine ( 215 ) , TRIM ( 212 ) , TTX ( 482 ) , tubacin ( 105 ) , tucatinib ( 53 ) , TUG-891 ( 116 ) , U0126 ( 48 , 56 , 59 , 66 , 89 , 102 , 148 , 164 , 166 , 172 , 196 , 201 , 213 , 226 , 240 , 245 , 261 , 266 , 285 , 292 , 302 , 306 , 314 , 329 , 360 , 370 , 386 , 388 , 391 , 427 , 438 , 441 , 451 , 452 , 463 , 473 , 481 , 483 , 484 , 513 , 515 , 516 , 517 , 522 , 531 , 546 ) , U73122 ( 314 ) , urethane ( 204 ) , UV ( 449 , 477 , 501 , 514 , 524 , 535 , 539 ) , UVB ( 300 ) , vasopressin ( 289 , 492 ) , VEGF ( 248 ) , virus infection ( 106 ) , visual experience ( 482 ) , vitronectin ( 474 ) , WIN ( 152 ) , wortmannin ( 215 , 245 , 261 , 266 , 314 , 391 , 522 , 548 ) , XL-147 ( 107 ) , Y27632 ( 494 ) , YM-254890 ( 116 ) , Zn(2+) ( 254 ) , zymosan ( 546 )

Downstream Regulation
Effects of modification on ERK1:	enzymatic activity, induced ( 35 , 181 , 303 , 459 , 468 , 509 , 528 , 553 ) , intracellular localization ( 196 )
Effects of modification on biological processes:	apoptosis, induced ( 39 ) , apoptosis, inhibited ( 230 , 233 ) , autophagy, inhibited ( 117 ) , carcinogenesis, induced ( 12 , 21 , 24 , 35 , 43 , 60 , 68 , 230 , 233 ) , carcinogenesis, inhibited ( 39 , 181 ) , cell cycle regulation ( 39 ) , cell differentiation, induced ( 93 ) , cell growth, induced ( 2 , 10 , 12 , 19 , 21 , 35 , 43 , 44 , 51 , 55 , 70 , 233 ) , cell growth, inhibited ( 39 , 181 ) , cell motility, induced ( 19 , 43 , 68 ) , cell motility, inhibited ( 39 ) , cytoskeletal reorganization ( 195 ) , neural plasticity ( 212 ) , signaling pathway regulation ( 35 , 195 , 196 ) , transcription, altered ( 66 , 546 ) , transcription, induced ( 21 , 24 , 31 , 134 ) , transcription, inhibited ( 49 )

Downstream Regulation

Effects of modification on ERK1:

enzymatic activity, induced ( 35 , 181 , 303 , 459 , 468 , 509 , 528 , 553 ) , intracellular localization ( 196 )

Effects of modification on biological processes:

apoptosis, induced ( 39 ) , apoptosis, inhibited ( 230 , 233 ) , autophagy, inhibited ( 117 ) , carcinogenesis, induced ( 12 , 21 , 24 , 35 , 43 , 60 , 68 , 230 , 233 ) , carcinogenesis, inhibited ( 39 , 181 ) , cell cycle regulation ( 39 ) , cell differentiation, induced ( 93 ) , cell growth, induced ( 2 , 10 , 12 , 19 , 21 , 35 , 43 , 44 , 51 , 55 , 70 , 233 ) , cell growth, inhibited ( 39 , 181 ) , cell motility, induced ( 19 , 43 , 68 ) , cell motility, inhibited ( 39 ) , cytoskeletal reorganization ( 195 ) , neural plasticity ( 212 ) , signaling pathway regulation ( 35 , 195 , 196 ) , transcription, altered ( 66 , 546 ) , transcription, induced ( 21 , 24 , 31 , 134 ) , transcription, inhibited ( 49 )

Disease / Diagnostics Relevance
Relevant diseases:	cancer, squamous cell carcinoma ( 264 ) , sickle-cell anaemia ( 10 )

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186	Ren H (2011) CST Curation Set: 12902; Year: 2011; Biosample/Treatment: /untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
187	Ren H (2011) CST Curation Set: 12904; Year: 2011; Biosample/Treatment: /untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
188	Ren H (2011) CST Curation Set: 12894; Year: 2011; Biosample/Treatment: primary cells, B lymphocyte/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
189	Ren H (2011) CST Curation Set: 12895; Year: 2011; Biosample/Treatment: /untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
190	Ren H (2011) CST Curation Set: 12896; Year: 2011; Biosample/Treatment: /untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
191	Ren H (2011) CST Curation Set: 12897; Year: 2011; Biosample/Treatment: /untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
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212	Gallo EF, Iadecola C (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci 31, 6947-55 21562256 Curated Info
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216	Mitra S, Lee JS, Cantrell M, Van den Berg CL (2011) c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8). J Biol Chem 286, 15287-97 21357683 Curated Info
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218	Saci A, Cantley LC, Carpenter CL (2011) Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 42, 50-61 21474067 Curated Info
219	Arora D, et al. (2011) Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem 286, 10918-29 21262971 Curated Info
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223	Kim DS, et al. (2011) Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. J Pharm Pharmacol 63, 409-16 21749389 Curated Info
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227	Peidis P, et al. (2011) Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death. Cell Death Differ 18, 145-54 20559319 Curated Info
228	Driessens G, et al. (2011) Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation. J Immunol 186, 784-90 21149602 Curated Info
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231	El Ayadi A, Zigmond MJ (2011) Low concentrations of methamphetamine can protect dopaminergic cells against a larger oxidative stress injury: mechanistic study. PLoS One 6, e24722 22022363 Curated Info
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236	Wu Z, et al. (2010) MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. J Clin Invest 120, 3901-11 20921625 Curated Info
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239	Chen X, et al. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem 285, 31268-76 20670933 Curated Info
240	Lysechko TL, Cheung SM, Ostergaard HL (2010) Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes. J Biol Chem 285, 31174-84 20688918 Curated Info
241	Sanderson MP, et al. (2010) Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol 48, 171-8 20828828 Curated Info
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255	Chuck MI, Zhu M, Shen S, Zhang W (2010) The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J Immunol 184, 2476-86 20130215 Curated Info
256	Zhou J (2010) CST Curation Set: 9105; Year: 2010; Biosample/Treatment: cell line, F9/untreated; Disease: testicular cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416 Curated Info
257	Zhou J (2010) CST Curation Set: 9104; Year: 2010; Biosample/Treatment: cell line, ES J1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416 Curated Info
258	Zhou J (2010) CST Curation Set: 9109; Year: 2010; Biosample/Treatment: cell line, P19/untreated; Disease: testicular cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416 Curated Info
259	Racaniello M, et al. (2010) Phosphorylation changes of CaMKII, ERK1/2, PKB/Akt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses. Neurochem Res 35, 239-46 19731018 Curated Info
260	Park YK, Park H (2010) Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis. J Biol Chem 285, 3289-99 19940121 Curated Info
261	Quoyer J, et al. (2010) GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem 285, 1989-2002 19915011 Curated Info
262	Liron T, Nahari T, Souroujon MC, Neumann D (2010) Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function. Biochem J 427, 305-12 20136632 Curated Info
263	Aguilar-Morante D, et al. (2010) Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8. PLoS One 5, e13879 21079728 Curated Info
264	Zhao L, et al. (2009) Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53. Cancer Res 69, 9439-47 19934324 Curated Info
265	Tucker M (2009) CST Curation Set: 8602; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Curated Info
266	Salmond RJ, Emery J, Okkenhaug K, Zamoyska R (2009) MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 183, 7388-97 19917692 Curated Info
267	Browne CD, et al. (2009) Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 31, 749-60 19896393 Curated Info
268	Tucker M (2009) CST Curation Set: 8084; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
269	Tucker M (2009) CST Curation Set: 8081; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
270	Tucker M (2009) CST Curation Set: 8088; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
271	Tucker M (2009) CST Curation Set: 8077; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) Rabbit mAb Cat#: 8954, Phospho-Tyrosine Rabbit mAb (p-Tyr-1000) Immunoaffinity Beads Cat#: 8876 Curated Info
272	Tucker M (2009) CST Curation Set: 8085; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
273	Tucker M (2009) CST Curation Set: 8080; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
274	Tucker M (2009) CST Curation Set: 8072; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) Rabbit mAb Cat#: 8954, Phospho-Tyrosine Rabbit mAb (p-Tyr-1000) Immunoaffinity Beads Cat#: 8876 Curated Info
275	Guo A (2009) CST Curation Set: 8168; Year: 2009; Biosample/Treatment: tissue, testis/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
276	Guo A (2009) CST Curation Set: 8166; Year: 2009; Biosample/Treatment: tissue, spleen/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
277	Guo A (2009) CST Curation Set: 8170; Year: 2009; Biosample/Treatment: tissue, thymus/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
278	Guo A (2009) CST Curation Set: 8167; Year: 2009; Biosample/Treatment: tissue, testis/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
279	Guo A (2009) CST Curation Set: 8169; Year: 2009; Biosample/Treatment: tissue, thymus/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
280	Guo A (2009) CST Curation Set: 8165; Year: 2009; Biosample/Treatment: tissue, spleen/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M) Curated Info
281	McPherson VA, et al. (2009) SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. J Immunol 183, 4940-7 19786542 Curated Info
282	Santamaría E, et al. (2009) Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition. Proteomics 9, 4495-506 19688729 Curated Info
283	Guo A (2009) CST Curation Set: 7709; Year: 2009; Biosample/Treatment: tissue, testis/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
284	Guo A (2009) CST Curation Set: 7708; Year: 2009; Biosample/Treatment: tissue, spleen/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
285	Joshi S, et al. (2009) Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proc Natl Acad Sci U S A 106, 12097-102 19574459 Curated Info
286	Zhou J (2009) CST Curation Set: 7383; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: QXp[ST] Curated Info
287	Possemato A (2009) CST Curation Set: 7168; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
288	Possemato A (2009) CST Curation Set: 7167; Year: 2009; Biosample/Treatment: cell line, RAW 264.7/LPS; Disease: leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
289	Sinnett-Smith J, et al. (2009) Protein Kinase D Mediates Mitogenic Signaling by Gq-coupled Receptors through Protein Kinase C-independent Regulation of Activation Loop Ser744 and Ser748 Phosphorylation. J Biol Chem 284, 13434-45 19289471 Curated Info
290	Lee DH, et al. (2009) Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem 284, 11776-80 19276091 Curated Info
291	Chung BM, et al. (2009) The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene 28, 1821-32 19305428 Curated Info
292	Tucker DE, et al. (2009) Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2{alpha} in Regulating Interfacial Kinetics and Binding and Cellular Function. J Biol Chem 284, 9596-611 19176526 Curated Info
293	Furusawa J, et al. (2009) Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol 9, 499-507 19291859 Curated Info
294	Li Y (2009) CST Curation Set: 6297; Year: 2009; Biosample/Treatment: cell line, MEF/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
295	Li Y (2009) CST Curation Set: 6299; Year: 2009; Biosample/Treatment: cell line, MEF Ras v12/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
296	Li Y (2009) CST Curation Set: 6296; Year: 2009; Biosample/Treatment: cell line, MEF/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
297	Catalanotti F, et al. (2009) A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16, 294-303 19219045 Curated Info
298	Choi JE, et al. (2009) Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury. Am J Respir Crit Care Med 179, 212-9 19011156 Curated Info
299	Olson LE, Soriano P (2009) Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16, 303-13 19217431 Curated Info
300	Kang NJ, et al. (2009) Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis 30, 321-30 19073879 Curated Info
301	Das M, et al. (2009) Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136, 249-60 19167327 Curated Info
302	van Gorp AG, et al. (2009) AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B. Oncogene 28, 95-106 18836482 Curated Info
303	Tallent MK, et al. (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284, 174-81 19004831 Curated Info
304	McPherson VA, et al. (2009) Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. Mol Cell Biol 29, 389-401 19001085 Curated Info
305	Lorenz K, Schmitt JP, Schmitteckert EM, Lohse MJ (2009) A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med 15, 75-83 19060905 Curated Info
306	Conche C, Boulla G, Trautmann A, Randriamampita C (2009) T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate. Immunity 30, 33-43 19144315 Curated Info
307	Ghisi V, et al. (2009) Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cell Signal 21, 87-94 18929645 Curated Info
308	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info
309	Zhou D, et al. (2008) The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A 105, 20321-6 19073936 Curated Info
310	Stokes M (2008) CST Curation Set: 5664; Year: 2008; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
311	Stokes M (2008) CST Curation Set: 5665; Year: 2008; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
312	Stokes M (2008) CST Curation Set: 5666; Year: 2008; Biosample/Treatment: cell line, Noonan Syndrome mouse heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
313	Stokes M (2008) CST Curation Set: 5667; Year: 2008; Biosample/Treatment: cell line, Noonan Syndrome mouse heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
314	Kuehn HS, et al. (2008) The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. J Immunol 181, 7706-12 19017959 Curated Info
315	Simon C, et al. (2008) Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112, 4039-47 18753636 Curated Info
316	Kaneda T, et al. (2008) Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis. Cancer Lett 270, 354-61 18606490 Curated Info
317	Mariappan MM, et al. (2008) Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells. J Biol Chem 283, 30566-75 18701453 Curated Info
318	Bécart S, et al. (2008) Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation. Immunity 29, 704-19 18976935 Curated Info
319	Bentzinger CF, et al. (2008) Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab 8, 411-24 19046572 Curated Info
320	Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85 18725415 Curated Info
321	Partovian C, et al. (2008) Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol Cell 32, 140-9 18851840 Curated Info
322	Rikova K (2008) CST Curation Set: 5291; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Curated Info
323	Rikova K (2008) CST Curation Set: 5292; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Curated Info
324	Rikova K (2008) CST Curation Set: 5293; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S3/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Curated Info
325	Rikova K (2008) CST Curation Set: 5296; Year: 2008; Biosample/Treatment: cell line, Dana Farber-KTL(LN)-4/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Curated Info
326	Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77 18515860 Curated Info
327	Noble C, et al. (2008) CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Mol Cell 31, 862-72 18922468 Curated Info
328	Takeda A, et al. (2008) Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice. Kobe J Med Sci 54, E183-90 19246967 Curated Info
329	Encinas M, et al. (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15, 1510-21 18497757 Curated Info
330	Hermann-Kleiter N, et al. (2008) The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity 29, 205-16 18701084 Curated Info
331	Rikova K (2008) CST Curation Set: 4985; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
332	Tchivilev I, et al. (2008) Identification of a protective role for protein phosphatase 1cgamma1 against oxidative stress-induced vascular smooth muscle cell apoptosis. J Biol Chem 283, 22193-205 18540044 Curated Info
333	Luo W, et al. (2008) Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res 7, 3447-60 18563927 Curated Info
334	Rikova K (2008) CST Curation Set: 4790; Year: 2008; Biosample/Treatment: cell line, Dana Farber-KT-1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
335	Rikova K (2008) CST Curation Set: 4771; Year: 2008; Biosample/Treatment: cell line, Dana Farber-KTL-1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
336	Rikova K (2008) CST Curation Set: 4839; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
337	Rikova K (2008) CST Curation Set: 4840; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
338	Rikova K (2008) CST Curation Set: 4763; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S1/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
339	Rikova K (2008) CST Curation Set: 4765; Year: 2008; Biosample/Treatment: cell line, Dana Farber-S2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
340	Cha HC, et al. (2008) Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes. J Biol Chem 283, 18002-11 18408001 Curated Info
341	Li Y (2008) CST Curation Set: 4544; Year: 2008; Biosample/Treatment: cell line, 10T1/2/FGF; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
342	Li Y (2008) CST Curation Set: 4543; Year: 2008; Biosample/Treatment: cell line, 10T1/2/FGF; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
343	Li Y (2008) CST Curation Set: 4542; Year: 2008; Biosample/Treatment: cell line, 10T1/2/FGF; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
344	Moore T, et al. (2008) Dietary energy balance modulates signaling through the Akt/mammalian target of rapamycin pathways in multiple epithelial tissues. Cancer Prev Res (Phila) 1, 65-76 19138937 Curated Info
345	Rikova K (2008) CST Curation Set: 4476; Year: 2008; Biosample/Treatment: cell line, MD Ander 1158(393P)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
346	Rikova K (2008) CST Curation Set: 4481; Year: 2008; Biosample/Treatment: cell line, MD Ander a0859/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
347	Oneyama C, et al. (2008) The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell 30, 426-36 18498747 Curated Info
348	Rikova K (2008) CST Curation Set: 4477; Year: 2008; Biosample/Treatment: cell line, MD Ander 1154/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
349	Rikova K (2008) CST Curation Set: 4478; Year: 2008; Biosample/Treatment: cell line, MD Ander 0895/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
350	Rikova K (2008) CST Curation Set: 4479; Year: 2008; Biosample/Treatment: cell line, MD Ander 1202(344SQ)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
351	Rikova K (2008) CST Curation Set: 4480; Year: 2008; Biosample/Treatment: cell line, MD Ander 1249/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
352	Rikova K (2008) CST Curation Set: 4474; Year: 2008; Biosample/Treatment: cell line, MD Ander 393LN/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
353	Rikova K (2008) CST Curation Set: 4437; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
354	Rikova K (2008) CST Curation Set: 4438; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
355	Rikova K (2008) CST Curation Set: 4439; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
356	Rikova K (2008) CST Curation Set: 4440; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
357	Bayascas JR, et al. (2008) Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol 28, 3258-72 18347057 Curated Info
358	Ren H (2008) CST Curation Set: 4335; Year: 2008; Biosample/Treatment: cell line, EGFR_WT/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
359	Ren H (2008) CST Curation Set: 4337; Year: 2008; Biosample/Treatment: cell line, Ras_WT/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
360	Yasuda T, et al. (2008) Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508 18356083 Curated Info
361	Wernig G, et al. (2008) Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 13, 311-20 18394554 Curated Info
362	Rikova K (2008) CST Curation Set: 4249; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
363	Rikova K (2008) CST Curation Set: 4250; Year: 2008; Biosample/Treatment: tissue, lung/Tarceva; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
364	Rikova K (2008) CST Curation Set: 4251; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
365	Rikova K (2008) CST Curation Set: 4252; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
366	Rikova K (2008) CST Curation Set: 4253; Year: 2008; Biosample/Treatment: tissue, lung/Tarceva; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
367	Rikova K (2008) CST Curation Set: 4254; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
368	Bakker W, et al. (2008) Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. Diabetes 57, 706-13 18086904 Curated Info
369	Samarakoon R, Higgins SP, Higgins CE, Higgins PJ (2008) TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling. J Mol Cell Cardiol 44, 527-38 18255094 Curated Info
370	Alejandro EU, Johnson JD (2008) Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis. J Biol Chem 283, 2407-17 18006502 Curated Info
371	Takatori A, et al. (2008) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development 135, 23-32 18032450 Curated Info
372	Ballif BA, Carey GR, Sunyaev SR, Gygi SP (2008) Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res 7, 311-8 18034455 Curated Info
373	Tyagi A, et al. (2007) Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 6, 3248-55 18089718 Curated Info
374	Hu HJ, et al. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 27, 13181-91 18045912 Curated Info
375	Ramshaw HS, et al. (2007) The Shc-binding site of the {beta}c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood 110, 3582-90 17638849 Curated Info
376	Cao L, et al. (2007) Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol 179, 5864-76 17947660 Curated Info
377	Gu T (2007) CST Curation Set: 3404; Year: 2007; Biosample/Treatment: cell line, Baf3(MSCV-NEO-FLT3/ITD)/IL3 withdrawal; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
378	Gu T (2007) CST Curation Set: 3405; Year: 2007; Biosample/Treatment: cell line, Baf3(MSCV-NEO-FLT3/ITD)/IL3 withdrawal; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
379	Schenning M, van Tiel CM, Wirtz KW, Snoek GT (2007) The anti-apoptotic MAP kinase pathway is inhibited in NIH3T3 fibroblasts with increased expression of phosphatidylinositol transfer protein beta. Biochim Biophys Acta 1773, 1664-71 17683809 Curated Info
380	Robinson MJ, et al. (2007) Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol Cell Biol 27, 7355-64 17709378 Curated Info
381	Le Y, et al. (2007) SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity 27, 811-23 18031698 Curated Info
382	Zaru R, et al. (2007) The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol 8, 1227-35 17906627 Curated Info
383	Yu J (2007) CST Curation Set: 3380; Year: 2007; Biosample/Treatment: cell line, Mouse Mesenchymal Stem Cells/bFGF; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
384	Yamanaka A, et al. (2007) Involvement of CaM kinase II in gonadotropin-releasing hormone-induced activation of MAP kinase in cultured hypothalamic neurons. Arch Biochem Biophys 466, 234-41 17706588 Curated Info
385	Cho YY, et al. (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res 67, 8104-12 17804722 Curated Info
386	Falin RA, Cotton CU (2007) Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site. J Gen Physiol 130, 313-28 17724164 Curated Info
387	McNeill L, et al. (2007) The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses. Immunity 27, 425-37 17719247 Curated Info
388	Merla R, et al. (2007) The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation. Am J Physiol Heart Circ Physiol 293, H1918-28 17616749 Curated Info
389	Jaeschke A, Davis RJ (2007) Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 27, 498-508 17679097 Curated Info
390	Li X, et al. (2007) Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation. Proc Natl Acad Sci U S A 104, 11597-602 17601773 Curated Info
391	Dong S, et al. (2007) 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells. Blood 110, 360-9 17389761 Curated Info
392	Yoshizaki T, et al. (2007) Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol 27, 5172-83 17515613 Curated Info
393	Takeshita S, et al. (2007) c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages. J Biol Chem 282, 18980-90 17420255 Curated Info
394	Schlaepfer DD, et al. (2007) Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem 282, 17450-9 17438336 Curated Info
395	Guo A (2007) CST Curation Set: 2987; Year: 2007; Biosample/Treatment: tissue, liver/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
396	Guo A (2007) CST Curation Set: 2988; Year: 2007; Biosample/Treatment: tissue, liver/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
397	Guo A (2007) CST Curation Set: 2989; Year: 2007; Biosample/Treatment: tissue, liver/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
398	Guo A (2007) CST Curation Set: 2990; Year: 2007; Biosample/Treatment: tissue, liver/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
399	Guo A (2007) CST Curation Set: 2983; Year: 2007; Biosample/Treatment: tissue, liver/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
400	Guo A (2007) CST Curation Set: 2984; Year: 2007; Biosample/Treatment: tissue, liver/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
401	Guo A (2007) CST Curation Set: 2985; Year: 2007; Biosample/Treatment: tissue, liver/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
402	Guo A (2007) CST Curation Set: 2986; Year: 2007; Biosample/Treatment: tissue, liver/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
403	Artemenko Y, Gagnon A, Ibrahim S, Sorisky A (2007) Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. J Cell Physiol 211, 598-607 17219406 Curated Info
404	Guo A (2007) CST Curation Set: 2923; Year: 2007; Biosample/Treatment: tissue, heart/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](D/E)X(D/E) Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) CKII Substrate Antibody (polyAb) Cat#: 5808, PTMScan(R) Phospho-CK Substrate Motif (S/TD/EXD/E) Immunoaffinity Beads Cat#: 1994 Curated Info
405	Toole BJ, Cohen PT (2007) The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Cell Signal 19, 1044-55 17257813 Curated Info
406	Xing K, et al. (2007) Low molecular weight protein tyrosine phosphatase (LMW-PTP) and its possible physiological functions of redox signaling in the eye lens. Biochim Biophys Acta 1774, 545-55 17428749 Curated Info
407	Guo A (2007) CST Curation Set: 2827; Year: 2007; Biosample/Treatment: tissue, heart/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
408	Jo M, et al. (2007) Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene 26, 2585-94 17043637 Curated Info
409	Li QJ, et al. (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129, 147-61 17382377 Curated Info
410	Khan N, et al. (2007) Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res 67, 3475-82 17389758 Curated Info
411	Guo A (2007) CST Curation Set: 2672; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
412	Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
413	Guo A (2007) CST Curation Set: 2677; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851 Curated Info
414	Guo A (2007) CST Curation Set: 2682; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851 Curated Info
415	Guo A (2007) CST Curation Set: 2564; Year: 2007; Biosample/Treatment: cell line, C2C12-D/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
416	Guo A (2007) CST Curation Set: 2565; Year: 2007; Biosample/Treatment: cell line, C2C12-D/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
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