Tyr7
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Home > Phosphorylation Site Page: > Tyr7  -  GRB2 (human)

Site Information
_MEAIAkyDFkATAD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478849

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 3 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PRLR (human) ( 3 )
Putative in vivo kinases:
JAK2 (human) ( 3 )
Treatments:
JAK2_inhibitor ( 3 ) , PRL ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, altered ( 3 )

References 

1

Moritz A (2009) CST Curation Set: 7814; Year: 2009; Biosample/Treatment: cell line, NCI-H358/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Moritz A (2009) CST Curation Set: 7815; Year: 2009; Biosample/Treatment: cell line, PANC-1/untreated; Disease: pancreatic carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Haines E, et al. (2009) Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol 29, 2505-20
19273609   Curated Info