Thr412
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Site Information
NQVFLGFtyVAPsVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448607

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 203 , 219 , 220 , 221 , 222 ) , electrophoretic mobility shift ( 214 ) , immunoassay ( 67 , 78 ) , immunoprecipitation ( 4 , 14 , 18 , 28 , 40 ) , mass spectrometry ( 4 , 18 , 100 , 221 ) , microscopy-colocalization with upstream kinase ( 39 ) , mutation of modification site ( 14 , 18 , 28 , 46 , 59 , 122 , 129 , 139 , 140 , 141 , 155 , 177 , 205 , 217 , 219 , 220 , 222 ) , peptide sequencing ( 29 , 219 , 221 ) , phospho-antibody ( 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 , 30 , 32 , 33 , 36 , 37 , 38 , 39 , 40 , 41 , 44 , 46 , 47 , 53 , 54 , 59 , 61 , 62 , 64 , 65 , 66 , 67 , 69 , 70 , 72 , 73 , 75 , 76 , 77 , 78 , 79 , 80 , 82 , 83 , 84 , 85 , 86 , 87 , 90 , 92 , 93 , 94 , 97 , 98 , 99 , 101 , 102 , 103 , 104 , 106 , 107 , 109 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 132 , 133 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 175 , 176 , 177 , 179 , 181 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 212 , 214 , 215 , 216 , 217 , 218 ) , phosphoamino acid analysis ( 95 , 203 , 220 , 221 ) , phosphopeptide mapping ( 219 , 220 , 221 , 222 ) , western blotting ( 4 , 5 , 6 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 44 , 46 , 47 , 53 , 54 , 59 , 61 , 62 , 64 , 65 , 66 , 67 , 70 , 72 , 73 , 75 , 76 , 77 , 79 , 80 , 82 , 83 , 84 , 85 , 86 , 87 , 90 , 92 , 93 , 94 , 95 , 98 , 99 , 101 , 102 , 103 , 104 , 106 , 107 , 109 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 132 , 133 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 158 , 159 , 160 , 162 , 164 , 171 , 173 , 175 , 176 , 177 , 179 , 185 , 186 , 187 , 189 , 190 , 191 , 192 , 193 , 194 , 197 , 198 , 200 , 202 , 203 , 204 , 207 , 208 , 210 , 212 , 216 , 217 , 218 )
Disease tissue studied:
bladder cancer ( 121 ) , bone cancer ( 72 , 92 , 104 , 106 , 128 , 160 ) , Ewing's sarcoma ( 106 , 128 ) , osteosarcoma ( 72 , 92 ) , brain cancer ( 10 , 77 , 99 , 104 , 150 , 158 ) , glioblastoma ( 10 , 77 , 99 , 104 , 150 , 158 ) , glioblastoma multiforme ( 150 , 158 ) , glioma ( 10 , 77 , 99 , 104 , 150 , 158 ) , breast cancer ( 16 , 19 , 20 , 26 , 32 , 44 , 47 , 61 , 75 , 76 , 86 , 87 , 90 , 103 , 104 , 107 , 113 , 114 , 117 , 119 , 122 , 125 , 145 , 153 , 154 , 157 , 162 , 200 , 203 ) , breast cancer, triple negative ( 32 ) , cervical cancer ( 116 , 189 ) , cervical squamous cell carcinoma ( 116 , 189 ) , colorectal cancer ( 33 , 76 , 121 , 124 , 141 , 177 ) , colorectal carcinoma ( 33 , 76 , 121 , 124 , 141 , 177 ) , gastric cancer ( 100 , 186 ) , gastric carcinoma ( 100 ) , GIST ( 186 ) , kidney cancer ( 82 , 85 ) , leukemia ( 6 , 12 , 54 , 148 , 157 ) , acute myelogenous leukemia ( 6 , 157 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 6 , 157 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 6 ) , chronic myelogenous leukemia ( 12 , 148 ) , T cell leukemia ( 54 ) , liver cancer ( 129 , 149 ) , lung cancer ( 5 , 7 , 8 , 13 , 23 , 25 , 75 , 90 , 104 , 113 , 114 , 130 , 195 ) , non-small cell lung cancer ( 5 , 7 , 8 , 13 , 23 , 25 , 113 , 130 ) , non-small cell lung adenocarcinoma ( 7 , 8 , 13 , 23 ) , non-small cell large cell lung carcinoma ( 7 , 8 , 23 ) , lymphoma ( 157 , 202 ) , neuroblastoma ( 73 ) , ovarian cancer ( 69 , 70 , 76 , 182 , 203 ) , ovarian epithelial carcinoma ( 69 ) , pancreatic cancer ( 173 ) , pancreatic carcinoma ( 173 ) , multiple myeloma ( 79 , 187 , 212 ) , prostate cancer ( 40 , 53 , 76 , 113 , 125 , 193 ) , melanoma skin cancer ( 62 , 122 ) , small intestine cancer ( 186 ) , fibrosarcoma of soft tissue ( 121 ) , rhabdomyosarcoma ( 24 , 106 , 128 ) , diabetes mellitus ( 117 ) , type 2 diabetes ( 117 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 192 ) , 'granulosa, luteal' ( 101 ) , 'kidney, tubule' [TSC2 (mouse), homozygous knockout] ( 82 ) , 'muscle, skeletal' ( 120 , 132 , 152 , 171 , 183 ) , 'muscle, smooth'-'heart, artery' ( 68 , 184 ) , 'neuron, hippocampal'-brain ( 192 ) , 1-LN (prostate cell) ( 40 ) , 293 (epithelial) ( 18 , 21 , 28 , 36 , 38 , 41 , 59 , 84 , 94 , 98 , 102 , 104 , 109 , 111 , 112 , 114 , 135 , 144 , 147 , 168 , 170 , 190 , 191 , 204 , 205 , 208 , 216 , 217 , 218 , 220 ) , 293 (epithelial) [IRS1 (human)] ( 137 ) , 293E (epithelial) ( 123 , 138 , 141 ) , 293FT ( 4 ) , 293T (epithelial) ( 4 , 12 , 14 , 46 , 62 , 97 , 140 , 141 , 147 , 166 , 167 , 168 , 172 ) , 3T3 (fibroblast) ( 38 , 130 , 147 , 220 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 163 , 188 ) , 3T3-L1 (fibroblast) ( 132 , 143 ) , 786-O (renal) ( 82 ) , A2780 (ovarian) ( 181 ) , A549 (pulmonary) ( 7 , 8 , 23 , 90 , 104 , 114 , 130 , 172 , 195 ) , adipocyte ( 146 ) , AF-10 (B lymphocyte) ( 212 ) , astrocyte-'brain, striatum' ( 198 ) , BAEC (endothelial) ( 142 ) , BaF3 ('B lymphocyte, precursor') ( 12 ) , BALB/MK (keratinocyte) ( 216 ) , BT-474 (breast cell) ( 75 , 203 ) , BV-173 (myeloid) ( 148 ) , C2C12 (myoblast) ( 164 ) , C2C12 (myoblast) [SPRY2 (human), transfection] ( 164 ) , Caco-2 (intestinal) ( 209 ) , Calu-1 (squamous) ( 130 ) , CCRF-CEM (T lymphocyte) ( 54 ) , cervix ( 116 ) , CHO (fibroblast) ( 66 , 132 , 176 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 218 ) , COS (fibroblast) ( 119 , 139 ) , DLD1 (intestinal) ( 121 ) , DU 145 (prostate cell) ( 40 , 113 , 193 ) , endothelial ( 93 ) , endothelial-aorta ( 159 ) , Fao (hepatic) ( 132 ) , fibroblast-skin ( 175 ) , FT210 (breast cell) ( 200 ) , FU-OV-1 (ovarian) ( 70 ) , GIST544 (gastric) ( 186 ) , GIST882 (gastric) ( 186 ) , GP293 (fibroblast) ( 12 ) , HaCaT (keratinocyte) ( 95 , 118 ) , HAEC (endothelial) ( 126 ) , HCC1806 (breast cell) ( 32 ) , HCC827 (pulmonary) ( 13 ) , HCT116 (intestinal) ( 121 , 124 , 177 ) , HCT15 (intestinal) ( 33 ) , heart ( 210 ) , HeLa (cervical) ( 4 , 14 , 24 , 37 , 39 , 65 , 67 , 84 , 90 , 99 , 113 , 115 , 132 , 138 , 141 , 147 , 149 , 151 , 155 , 172 , 200 ) , HeLa S3 (cervical) ( 155 ) , HepG2 (hepatic) ( 129 , 143 , 149 ) , HK2 (epithelial) ( 82 ) , HL60 (myeloid) ( 196 ) , HMVEC (endothelial) ( 206 ) , HN5 (squamous) ( 169 ) , HPB-ALL (T lymphocyte) ( 202 ) , HT-29 (intestinal) ( 76 , 124 , 141 , 172 , 199 ) , HT1080 (fibroblast) ( 121 ) , HTR8/SVneo (trophoblast) ( 179 ) , HUVEC (endothelial) ( 15 , 121 , 146 , 176 ) , IMR-90 (fibroblast) ( 64 , 80 ) , JB (epithelial) ( 215 ) , Jurkat (T lymphocyte) ( 83 , 202 ) , K562 (erythroid) ( 12 , 148 ) , Karpas-707 (B lymphocyte) ( 187 ) , Kasumi-1 (myeloid) ( 6 ) , KB (squamous) ( 189 ) , KG-1 (myeloid) ( 6 , 157 ) , KG-1a (myeloid) ( 6 ) , kidney ( 85 ) , L6 (myoblast) ( 18 , 132 , 137 , 207 ) , LCL (lymphoblastoid) ( 78 ) , liver ( 117 ) , LN229 (glial) ( 10 , 158 ) , lung ( 11 , 13 ) , M059J (glial) ( 133 ) , macrophage-bone marrow ( 9 ) , MCF-10A (breast cell) ( 19 , 76 ) , MCF-10A (breast cell) [GAB2 (human), transfection] ( 119 ) , MCF-7 (breast cell) ( 19 , 26 , 61 , 86 , 87 , 103 , 104 , 107 , 113 , 122 , 125 , 145 , 153 , 154 , 157 , 162 , 165 ) , MDA-MB-231 (breast cell) ( 20 , 26 , 47 , 76 , 114 , 125 ) , MDA-MB-361 (breast cell) ( 92 ) , MDA-MB-435 (breast cell) ( 44 , 90 ) , MDA-MB-453 (breast cell) ( 117 ) , MDA-MB-468 (breast cell) ( 114 ) , MEF (fibroblast) ( 4 , 19 , 65 , 102 , 130 , 133 , 141 , 147 , 185 ) , MEF (fibroblast) [RICTOR (human), homozygous knockout] ( 84 ) , MEF (fibroblast) [TSC2 (mouse), heterozygous knockout] ( 82 ) , mesenchymal ( 11 ) , MG63 (bone cell) ( 72 , 92 ) , MKN-45 (gastric) ( 100 ) , MM (B lymphocyte) ( 79 ) , MRC5 (fibroblast) ( 121 ) , myeloid-bone marrow ( 127 ) , myoblast ( 171 ) , myocyte-heart ( 194 ) , NB-4 (myeloid) ( 157 ) , NCI-H1299 (pulmonary) ( 5 ) , NCI-H157 (pulmonary) ( 113 , 130 ) , NCI-H1975 (pulmonary) ( 7 , 8 ) , NCI-H292 (pulmonary) ( 75 ) , NCI-H460 (pulmonary) ( 7 , 8 , 23 ) , neutrophil ( 197 ) , OPM-2 (plasma cell) ( 79 ) , ovary ( 69 , 182 ) , OVCAR3 (ovarian) ( 70 , 181 ) , OVCAR4 (ovarian) ( 182 ) , OVCAR5 (ovarian) ( 182 ) , pancreas ( 173 ) , PC3 (prostate cell) ( 40 , 53 , 76 , 125 , 172 , 193 ) , PC9 (pulmonary) ( 13 ) , preadipocyte ( 146 ) , Rat1 (fibroblast) ( 133 ) , Rh1 (bone cell) ( 106 , 128 ) , Rh18 (muscle cell) ( 128 ) , Rh30 (muscle cell) ( 24 , 106 , 128 ) , Rh41 ( 128 ) , RPMI-8226 (plasma cell) ( 79 ) , SF9 ( 59 ) , SH-SY5Y (neural crest) ( 73 , 161 ) , SK-MEL28 (melanocyte) ( 62 ) , SK-MEL3 (melanocyte) ( 62 ) , SK-MEL5 (melanocyte) ( 62 ) , SKBr3 (breast cell) ( 75 , 114 , 203 ) , SKOV-3 (ovarian) ( 70 , 76 , 182 , 203 ) , SNB-19 (glial) ( 158 ) , SW48 (intestinal) ( 33 ) , SW620 (intestinal) ( 33 ) , Swiss 3T3 (fibroblast) ( 221 , 222 ) , T24 (bladder cell) ( 121 ) , T47D (breast cell) ( 16 ) , T98G (glial) ( 150 ) , TF-1 (erythroid) ( 157 ) , TOV21G (ovarian) ( 70 ) , U-937 (myeloid) ( 157 , 202 ) , U251 (glial) ( 99 , 158 ) , U266 (plasma cell) ( 79 ) , U2OS (bone cell) ( 104 , 160 ) , U373 MG (glial) ( 158 ) , U87MG (glial) ( 77 , 104 , 158 ) , WM35 (melanocyte) ( 122 ) , WM793 ( 76 )

Upstream Regulation
Regulatory protein:
ACSL4 (human) ( 16 ) , Akt1 (human) ( 64 , 84 , 109 , 130 ) , Akt2 (human) ( 109 ) , AMPKA1 (human) ( 118 , 142 ) , ARL8B (human) ( 67 ) , ATG13 (human) ( 112 ) , CK1E (human) ( 36 ) , DDIT4 (human) ( 170 ) , DDIT4L (human) ( 170 ) , DDX48 (human) ( 123 ) , DUSP6 (human) ( 210 ) , DYRK3 (human) ( 39 ) , FAK (human) ( 147 ) , FLCN (human) ( 37 ) , FOXO1A (human) ( 146 ) , FRS2 (human) ( 154 ) , GSK3A (human) ( 19 ) , GSK3B (human) ( 19 , 32 ) , HERC1 (human) ( 54 ) , HRas (human) ( 64 ) , KHS2 (human) ( 97 ) , LAMTOR1 (human) ( 94 ) , LAMTOR2 (human) ( 94 ) , LAMTOR3 (human) ( 94 ) , LST8 (human) ( 109 ) , MAGE-A6 (human) ( 27 ) , MAGEA3 (human) ( 27 ) , MKK6 (human) ( 55 ) , Mnk1 (human) ( 130 ) , mTOR (human) ( 54 , 80 , 84 , 98 , 106 , 109 , 114 , 125 , 126 ) , Notch 1 (human) ( 156 ) , OSBPL9 (human) ( 144 ) , p27Kip1 (human) ( 93 ) , p70S6K (human) ( 70 , 123 , 178 ) , PIK3C2B (human) ( 54 ) , PKCA (human) ( 83 ) , PKM (human) ( 5 , 14 ) , PKM iso2 (human) ( 5 ) , PLK1 (human) ( 160 ) , PPP2CA (human) ( 61 ) , PRAS40 iso3 (human) ( 141 ) , PRKD1 (human) ( 25 ) , RAF1 (human) ( 210 ) , Raptor (human) ( 11 , 24 , 66 , 84 , 94 , 98 , 109 , 111 , 122 , 126 , 141 ) , Ret (human) ( 86 ) , RHEB (human) ( 11 , 28 , 98 , 111 , 153 , 167 ) , RICTOR (human) ( 24 , 84 , 109 , 114 , 126 ) , RMP (human) ( 70 ) , RRAGA (human) ( 94 ) , RRAGB (human) ( 94 ) , Sin1 (human) ( 109 , 114 ) , SKAR (human) ( 123 ) , SLC1A5 (human) ( 115 , 136 ) , SLC3A2 (human) ( 115 ) , SLC7A5 (human) ( 115 ) , SMPD3 (human) ( 61 ) , SPRY2 (human) ( 164 ) , TRAF2 (human) ( 26 ) , TRAF4 (human) ( 26 ) , TSC1 (human) ( 117 , 151 , 160 ) , TSC1 (mouse) ( 185 ) , TSC2 (human) ( 11 , 118 , 147 , 149 , 151 , 153 , 160 , 191 ) , TSC2 (mouse) ( 185 ) , ULK1 (human) ( 112 , 140 ) , ULK2 (human) ( 112 , 140 )
Putative in vivo kinases:
mTOR (human) ( 111 , 166 , 172 , 204 ) , p70S6K (human) ( 205 ) , PDK1 (human) ( 59 , 205 , 217 ) , PIK3CA (human) ( 213 )
Kinases, in vitro:
mTOR (human) ( 59 , 81 , 141 , 166 , 172 ) , NEK6 (human) ( 208 ) , PDK1 (human) ( 217 )
Phosphatases, in vitro:
PHLPP (human) ( 43 ) , PHLPP2 (human) ( 43 )
Treatments:
1,25_dihydroxyvitamin_D ( 72 ) , 1,25D ( 209 ) , 1-azakenpaullone ( 32 ) , 2-deoxyglucose ( 98 , 191 ) , 3-Methyladenine ( 77 ) , 5(S)-HETE ( 206 ) , 5-cholesten-5-beta-ol ( 95 ) , 8-CPT-2Me-cAMP ( 40 ) , A-443654 ( 134 ) , acadesine ( 82 , 118 ) , AG1024 ( 184 ) , AG1296 ( 127 ) , AG1478 ( 95 , 174 ) , AG490 ( 127 , 206 ) , alpelisib ( 10 ) , ALW-II-41-27 ( 13 ) , amino_acid_starvation ( 62 , 94 , 128 , 143 , 167 ) , amino_acids ( 4 , 35 , 94 , 102 , 115 , 122 , 171 , 188 ) , angiotensin ( 174 , 184 ) , anisomycin ( 163 , 188 ) , anti-HLA ( 126 ) , anti-ITGB1 ( 194 ) , anti-ITGB3 ( 194 ) , anti-TNFalpha ( 26 ) , apelin ( 176 ) , APV ( 192 ) , AR-A014418 ( 32 ) , aspirin ( 216 ) , ATP ( 145 ) , AZD8055 ( 11 , 104 ) , bisindolylmaleimide ( 177 , 194 , 210 ) , blood pressure ( 210 ) , calyculin_A ( 76 ) , carbachol ( 198 ) , Cbz-B3A ( 12 ) , CGP57380 ( 130 ) , cholesterol_oxidase ( 95 ) , colforsin ( 210 ) , compound_C ( 118 , 142 ) , cycloheximide ( 39 ) , dactolisib ( 29 ) , DAMGO ( 218 ) , depolarization ( 192 ) , dexamethasone ( 187 ) , dinoprost ( 101 ) , EGF ( 39 , 47 , 59 , 119 , 128 , 140 , 158 , 177 , 179 , 199 , 205 , 215 , 216 ) , ephrin_A1 ( 76 ) , Epo ( 201 ) , erlotinib ( 169 ) , estradiol ( 122 , 153 ) , ethanol ( 76 , 198 , 216 ) , exercise ( 152 , 183 ) , FCCP ( 191 ) , FGF1 ( 154 ) , FGF2 ( 164 ) , fibronectin ( 147 ) , Filipin ( 95 ) , fingolimod ( 202 ) , FK506 ( 197 , 222 ) , fluoromethylketone ( 155 ) , GDNF ( 86 ) , GF109203X ( 176 ) , glucose ( 214 ) , glucose_starvation ( 137 , 191 ) , glutamic acid ( 115 , 192 ) , GM-CSF ( 197 ) , Go_6796 ( 11 ) , GSK-626616 ( 39 ) , H2O2 ( 118 ) , herbimycin_A ( 176 ) , heregulin ( 154 ) , IFN-gamma ( 195 ) , IGF-1 ( 68 , 79 , 106 , 128 , 135 , 169 , 171 , 187 , 207 , 208 , 212 , 217 ) , IL-6 ( 129 , 187 , 212 ) , imatinib ( 29 , 76 , 186 ) , indometacin ( 216 ) , INK-128 ( 33 ) , insulin ( 31 , 39 , 41 , 66 , 84 , 98 , 102 , 103 , 109 , 110 , 111 , 115 , 120 , 122 , 123 , 128 , 134 , 137 , 141 , 143 , 149 , 155 , 163 , 164 , 178 , 185 , 188 , 189 , 194 , 210 , 214 ) , ionizing_radiation ( 162 ) , ionomycin ( 145 ) , itraconazol ( 15 ) , JQ1 ( 6 ) , kb_NB_142-70 ( 25 ) , KP-372-1 ( 157 , 158 ) , KP-372-2 ( 158 ) , KU-0063794 ( 33 ) , L-744,832 ( 216 ) , laminar flow ( 142 ) , leucine_deprivation ( 62 ) , liothyronine ( 175 ) , long-term_potentiation ( 192 ) , LPS ( 195 ) , LY294002 ( 40 , 76 , 84 , 95 , 102 , 109 , 130 , 150 , 154 , 166 , 175 , 179 , 181 , 182 , 184 , 192 , 193 , 195 , 196 , 201 , 206 , 216 , 218 ) , meal feeding ( 171 ) , medium change ( 115 , 140 ) , metformin ( 87 ) , methyl-beta-cyclodextrin ( 95 ) , methylxanthine ( 222 ) , mifepristone ( 136 ) , miR-451 ( 99 ) , MK-2206 ( 11 ) , monensin ( 194 ) , monodansylcadaverine ( 194 ) , naloxone ( 218 ) , NBQX ( 192 ) , nifedipine ( 192 ) , nilotinib ( 29 ) , NMDA ( 192 ) , nocodazole ( 67 , 200 ) , okadaic_acid ( 61 , 188 , 202 ) , oscillatory_flow ( 142 ) , osteopontin ( 107 ) , paracetamol ( 216 ) , PD98059 ( 76 , 176 , 192 , 197 , 202 , 212 , 215 , 218 ) , pemetrexed ( 7 , 8 ) , peptide inhibitor ( 217 ) , PF-670462 ( 36 ) , phorbol_ester ( 25 , 30 , 98 , 103 , 168 , 176 , 194 , 210 , 215 , 216 ) , PI-103 ( 102 , 121 ) , picropodophyllin ( 68 ) , pimenta doica ( 20 ) , PKC_inhibitor_myristoylated ( 176 ) , PP1 ( 184 , 207 ) , PP2 ( 126 , 127 , 176 ) , PP242 ( 33 , 79 ) , PTX ( 176 , 218 ) , QLT0254 ( 173 ) , RAD001 ( 39 ) , rapamycin ( 11 , 12 , 14 , 19 , 23 , 28 , 30 , 32 , 38 , 40 , 44 , 47 , 49 , 54 , 55 , 64 , 70 , 76 , 79 , 80 , 82 , 86 , 87 , 90 , 93 , 98 , 101 , 102 , 103 , 104 , 107 , 110 , 112 , 114 , 115 , 119 , 121 , 122 , 123 , 124 , 127 , 128 , 129 , 130 , 134 , 135 , 138 , 142 , 149 , 150 , 153 , 154 , 155 , 156 , 162 , 163 , 165 , 166 , 171 , 176 , 177 , 179 , 181 , 182 , 185 , 187 , 188 , 189 , 192 , 193 , 194 , 197 , 201 , 208 , 209 , 210 , 212 , 215 , 216 , 218 , 221 , 222 ) , resveratrol ( 77 ) , retinoic_acid ( 61 ) , RGD ( 194 ) , rosiglitazone ( 16 ) , rottlerin ( 191 ) , salicylate ( 216 ) , SB202190 ( 210 , 215 ) , SB203580 ( 86 , 150 , 210 , 216 ) , SB216763 ( 23 ) , SCF ( 186 ) , seocalcitol ( 145 ) , serum ( 67 , 94 , 98 , 109 , 134 , 138 , 141 , 150 , 155 , 164 , 181 , 193 , 197 , 222 ) , serum_starvation ( 70 , 115 ) , serum_withdrawal ( 72 ) , SGI-1776 ( 10 ) , SH-6 ( 176 ) , sildenafil ( 7 , 8 ) , silmitasertib ( 53 ) , simvastatin ( 95 ) , siRNA ( 70 , 114 , 122 , 123 , 125 , 130 , 141 , 144 , 147 , 149 , 153 , 159 , 160 , 178 , 191 ) , sorafenib ( 7 ) , sorbitol ( 39 ) , SP600125 ( 86 , 163 ) , sphingosine_1-phosphate ( 159 ) , taxol ( 203 ) , temsirolimus ( 92 ) , thapsigargin ( 145 ) , tioguanine ( 124 ) , Torin1 ( 30 , 37 , 44 ) , U0126 ( 30 , 47 , 86 , 101 , 103 , 138 , 150 , 154 , 155 , 168 , 177 , 179 , 189 , 194 , 210 , 212 ) , UV ( 118 , 215 ) , vanadate ( 207 ) , wortmannin ( 11 , 86 , 95 , 98 , 109 , 110 , 119 , 130 , 142 , 143 , 153 , 175 , 176 , 179 , 185 , 189 , 194 , 195 , 199 , 202 , 210 , 212 , 215 , 218 , 222 ) , WYE132 ( 92 ) , Zn(2+) ( 161 )

Downstream Regulation
Effects of modification on p70S6K:
enzymatic activity, induced ( 67 , 116 , 139 , 190 , 195 , 196 , 199 , 213 , 220 , 221 , 222 ) , intracellular localization ( 116 ) , phosphorylation ( 140 )
Effects of modification on biological processes:
cell adhesion, altered ( 177 ) , cell cycle regulation ( 181 , 209 ) , cell growth, induced ( 26 ) , translation, altered ( 220 )

Disease / Diagnostics Relevance
Relevant diseases:
cervical squamous cell carcinoma ( 116 ) , acute myelogenous leukemia ( 127 ) , ovarian epithelial carcinoma ( 69 ) , hypertrophic cardiomyopathy ( 91 ) , type 2 diabetes ( 132 )

References 

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