Thr148
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Home > Phosphorylation Site Page: > Thr148  -  AMPKB1 (human)

Site Information
IVTsQLGtVNNIIQV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7447514

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , liver cancer ( 2 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HEK293T (epithelial) ( 2 ) , HepG2 (hepatic) ( 2 ) , Jurkat (T lymphocyte) ( 3 ) , MDA-MB-435S (breast cell) ( 4 )

Upstream Regulation
Kinases, in vitro:
AMPKA1 (human) ( 2 )
Treatments:
A-769662 ( 2 ) , acadesine ( 2 ) , glucose_starvation ( 2 ) , insulin ( 2 ) , oligomycin ( 2 ) , phenformin ( 2 )

Downstream Regulation
Effects of modification on AMPKB1:
molecular association, regulation ( 2 )
Inhibit interaction with:
Other ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Oligschlaeger Y, et al. (2015) The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation. J Biol Chem 290, 11715-28
25792737   Curated Info

3

Guo A (2011) CST Curation Set: 11891; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

4

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

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