Ser483
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Home > Phosphorylation Site Page: > Ser483  -  RIOK2 (human)

Site Information
QYRTRtLsItssGsA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7446950

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 4 ) , chronic myelogenous leukemia ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 293E (epithelial) ( 3 ) , Jurkat (T lymphocyte) ( 2 ) , K562 (erythroid) ( 4 ) , MV4-11 (macrophage) ( 5 )

Upstream Regulation
Regulatory protein:
RSK3 (human) ( 1 ) , RSK4 (human) ( 1 )
Putative in vivo kinases:
p90RSK (human) ( 1 ) , RSK2 (human) ( 1 )
Kinases, in vitro:
p90RSK (human) ( 1 )
Treatments:
EGF ( 1 ) , LJH685 ( 1 ) , PD184352 ( 1 ) , phorbol_ester ( 1 ) , serum ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on RIOK2:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Inhibit interaction with:
NOB1P (human) ( 1 )

References 

1

Cerezo EL, et al. (2021) RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit. PLoS Genet 17, e1009583
34125833   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

4

Beausoleil S (2010) CST Curation Set: 10280; Year: 2010; Biosample/Treatment: cell line, K-562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

5

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

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