Tyr686
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Home > Phosphorylation Site Page: > Tyr686  -  PDGFRB (human)

Site Information
IITEyCRyGDLVDyL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7437801

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 4 ) , western blotting ( 4 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 ) , neuroblastoma ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 4 ) , Arg (human) ( 4 )

Downstream Regulation
Effects of modification on PDGFRB:
enzymatic activity, induced ( 4 )
Effects of modification on biological processes:
cell motility, altered ( 4 )

References 

1

Palacios-Moreno J, et al. (2015) Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts. PLoS Comput Biol 11, e1004130
25884760   Curated Info

2

Johnson H, White FM (2014) Quantitative analysis of signaling networks across differentially embedded tumors highlights interpatient heterogeneity in human glioblastoma. J Proteome Res 13, 4581-93
24927040   Curated Info

3

Guo A (2010) CST Curation Set: 10548; Year: 2010; Biosample/Treatment: cell line, SKNBE(2)/NGF; Disease: neuroblastoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Srinivasan D, Kaetzel DM, Plattner R (2009) Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal 21, 1143-50
19275932   Curated Info