Lys442
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Home > Acetylation Site Page: > Lys442  -  Huntingtin (human)

Site Information
LsRKQKGkVLLGEEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7434500

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , modification-specific antibody ( 1 , 2 ) , mutation of modification site ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 2 ) , COS7 (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 ) , Neuro-2a (neuron) ( 2 )

Upstream Regulation
Regulatory protein:
HAT1 (human) ( 2 ) , MYST2 (human) ( 2 ) , p300 (human) ( 2 ) , PCAF (human) ( 2 ) , Tip60 (human) ( 2 )
Treatments:
nicotinamide ( 2 ) , siRNA ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on Huntingtin:
intracellular localization ( 2 ) , protein degradation ( 2 )
Effects of modification on biological processes:
autophagy, induced ( 2 )

References 

1

Cong X, et al. (2011) Mass spectrometric identification of novel lysine acetylation sites in huntingtin. Mol Cell Proteomics 10, M111.009829
21685499   Curated Info

2

Jeong H, et al. (2009) Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137, 60-72
19345187   Curated Info

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