Ser2996
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Home > Phosphorylation Site Page: > Ser2996  -  ATM (human)

Site Information
QECkRNLsDIDQSFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7433302

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 , 8 , 9 , 10 , 11 , 12 ) , multiple reaction monitoring (MRM) ( 1 ) , phospho-antibody ( 8 ) , western blotting ( 8 )
Disease tissue studied:
ataxia-telangiectasia ( 8 ) , lung cancer ( 5 ) , non-small cell lung adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 1 , 8 )
Kinases, in vitro:
ATM (human) ( 8 )
Treatments:
galunisertib ( 1 ) , ionizing_radiation ( 1 , 8 , 10 ) , KU-55933 ( 8 ) , wortmannin ( 8 )

Downstream Regulation
Effects of modification on ATM:
enzymatic activity, induced ( 8 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , DNA repair, induced ( 1 )

References 

1

Liu Q, et al. (2021) Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Sci Transl Med 13
33568520   Curated Info

2

Li X, et al. (2020) A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents. J Virol
32796077   Curated Info

3

Lee HJ, et al. (2015) Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25, 225-36
25601159   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

6

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

7

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

8

Kozlov SV, et al. (2011) Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem 286, 9107-19
21149446   Curated Info

9

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

10

Bennetzen MV, et al. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 9, 1314-23
20164059   Curated Info

11

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

12

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info