Tyr37
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Home > Phosphorylation Site Page: > Tyr37  -  GRB2 (human)

Site Information
EECDQNWykAELNGk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7388001

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PRLR (human) ( 1 )
Putative in vivo kinases:
JAK2 (human) ( 1 )
Treatments:
JAK2_inhibitor ( 1 ) , PRL ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, altered ( 1 )

References 

1

Haines E, et al. (2009) Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol 29, 2505-20
19273609   Curated Info