Ser868
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Home > Phosphorylation Site Page: > Ser868  -  GluR6 (human)

Site Information
MVEELRMsLKcQRRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478417

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Treatments:
chelerythrine ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on GluR6:
molecular association, regulation ( 1 ) , receptor internalization, induced ( 1 ) , receptor recycling, induced ( 1 ) , sumoylation ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 )
Induce interaction with:
EEA1 (human) ( 1 ) , TfR (human) ( 1 )

References 

1

Chamberlain SE, et al. (2012) SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity. Nat Neurosci 15, 845-52
22522402   Curated Info