Tyr384
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Home > Phosphorylation Site Page: > Tyr384  -  TIAM1 (mouse)

Site Information
DRARQGVyENFRREL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7362700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 2 ) , MDCK (epithelial) ( 2 ) , MEF (fibroblast) ( 2 ) , PYS-2 (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 )
Kinases, in vitro:
Src (human) ( 2 )
Treatments:
HGF ( 2 ) , PP2 ( 2 ) , SU6656 ( 2 ) , vanadate ( 2 )

Downstream Regulation
Effects of modification on TIAM1:
molecular association, regulation ( 2 ) , protein degradation ( 2 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
ERK1 (human) ( 2 ) , ERK2 (human) ( 2 ) , GRB2 (human) ( 2 )

References 

1

Zhou J (2010) CST Curation Set: 9108; Year: 2010; Biosample/Treatment: cell line, PY2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

2

Woodcock SA, et al. (2009) SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell 33, 639-53
19285946   Curated Info