Thr79
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Home > Phosphorylation Site Page: > Thr79  -  EWS (human)

Site Information
QPPTGYTtPTAPQAY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7359501

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bone cancer ( 2 ) , Ewing's sarcoma ( 1 , 2 ) , colorectal cancer ( 1 , 2 ) , colorectal carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , A673 (muscle cell) ( 1 ) , DLD1 (intestinal) ( 1 ) , HCT116 (intestinal) ( 2 ) , HeLa (cervical) ( 1 ) , RD-ES (bone cell) ( 2 ) , SK-ES-1 ( 2 )

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 2 ) , ATR (human) ( 2 ) , ERK1 (human) ( 2 ) , ERK2 (human) ( 2 ) , JNK1 iso2 (human) ( 2 ) , P38A (human) ( 2 ) , P38B (human) ( 2 )
Kinases, in vitro:
ERK2 (human) ( 2 ) , JNK1 iso2 (human) ( 2 ) , P38A (human) ( 2 )
Treatments:
BIRB-0796 ( 2 ) , EGF ( 2 ) , KU-55933 ( 2 ) , MMS ( 2 ) , PD184352 ( 2 ) , phorbol_ester ( 2 ) , SB203580 ( 2 ) , U0126 ( 2 ) , UV ( 2 )

Downstream Regulation
Effects of modification on EWS:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )
Induce interaction with:
AurB (human) ( 1 )

References 

1

Park H, et al. (2020) Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy. J Biol Chem
33293370   Curated Info

2

Klevernic IV, Morton S, Davis RJ, Cohen P (2009) Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. Biochem J 418, 625-34
19076070   Curated Info

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