Ser475
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Home > Phosphorylation Site Page: > Ser475  -  FOXO1A (mouse)

Site Information
PPHNDIMsPVDPGVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478372

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phosphopeptide mapping ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
hepatocyte-liver ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (mouse) ( 3 ) , P38A (mouse) ( 3 )
Kinases, in vitro:
ERK2 (mouse) ( 3 ) , P38A (mouse) ( 3 )

Downstream Regulation
Effects of modification on FOXO1A:
intracellular localization ( 1 )

References 

1

Ozcan L, et al. (2012) Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab 15, 739-51
22503562   Curated Info

2

Jiao P, Feng B, Xu H (2012) Mapping MKP-3/FOXO1 Interaction and Evaluating the Effect on Gluconeogenesis. PLoS One 7, e41168
22848439   Curated Info

3

Asada S, et al. (2007) Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 19, 519-27
17113751   Curated Info