Ser478
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Home > Phosphorylation Site Page: > Ser478  -  TrkB (mouse)

Site Information
SNDDDsAsPLHHISN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478364

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain [TrkB (mouse), transgenic] ( 1 ) , 293 (epithelial) ( 3 ) , brain ( 2 ) , HEK293T (epithelial) ( 1 ) , neuron-'brain, cerebral cortex' ( 3 ) , neuron-'brain, hippocampus' ( 3 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (mouse) ( 1 , 3 )
Kinases, in vitro:
CDK5 (mouse) ( 3 )
Treatments:
BDNF ( 1 , 3 ) , bicuculline ( 1 ) , glycine ( 1 ) , seliciclib ( 3 )

Downstream Regulation
Effects of modification on TrkB:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 3 )
Induce interaction with:
TIAM1 (mouse) ( 1 )

References 

1

Lai KO, et al. (2012) TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci 15, 1506-15
23064382   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Cheung ZH, et al. (2007) Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol 5, e63
17341134   Curated Info