Ser139
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Home > Phosphorylation Site Page: > Ser139  -  NSUN2 (human)

Site Information
SRKILRksPHLEkFH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478355

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 2 )
Kinases, in vitro:
AurB (human) ( 2 )

Downstream Regulation
Effects of modification on NSUN2:
enzymatic activity, inhibited ( 1 , 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:
NCL (human) ( 2 )
Inhibit interaction with:
NPM1 (human) ( 2 )

References 

1

Okamoto M, et al. (2014) tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells. PLoS Genet 10, e1004639
25233213   Curated Info

2

Sakita-Suto S, et al. (2007) Aurora-B regulates RNA methyltransferase NSUN2. Mol Biol Cell 18, 1107-17
17215513   Curated Info