Ser6

Site Information
__MEPDNsPRKIQFT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 478275

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 ) , phospho-antibody ( 4 , 5 ) , western blotting ( 5 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 2 ) , 'neuron, striatal'-brain ( 4 ) , brain ( 3 )

Upstream Regulation
Putative in vivo kinases:	CDK5 (human) ( 5 )
Treatments:	AMPA ( 5 ) , APV ( 5 ) , calyculin_A ( 5 ) , depolarization ( 5 ) , EGTA ( 5 ) , insulin ( 2 ) , kainic_acid ( 5 ) , LY294002 ( 2 ) , MK801 ( 5 ) , Ni(2+) ( 5 ) , nimodipine ( 5 ) , NMDA ( 5 ) , okadaic_acid ( 5 ) , phorbol_ester ( 4 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20 23684622 Curated Info
3	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
4	Sahin B, et al. (2008) Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Eur J Pharmacol 581, 270-5 18190909 Curated Info
5	Nguyen C, et al. (2007) Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization. J Neurochem 103, 1582-93 17868322 Curated Info