Ser334
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Home > Phosphorylation Site Page: > Ser334  -  USP20 (mouse)

Site Information
RMKDRKFsWGQQRTN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7323248

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 , 5 , 6 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 , 4 ) , 293 (epithelial) ( 1 ) , liver ( 5 ) , liver [leptin (mouse), homozygous knockout] ( 5 ) , myocyte-heart ( 1 ) , T lymphocyte-spleen ( 6 )

Upstream Regulation
Regulatory protein:
PKACA (mouse) ( 1 )
Putative in vivo kinases:
PKACA (mouse) ( 1 )
Treatments:
dobutamine ( 1 ) , isoproterenol ( 1 )

Downstream Regulation
Effects of modification on USP20:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Induce interaction with:
ADRB1 (mouse) ( 1 )

References 

1

Yu SM, et al. (2018) The deubiquitinase ubiquitin specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling. J Biol Chem
30538132   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

6

Navarro MN, et al. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12, 352-61
21399638   Curated Info