Ser143
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Home > Phosphorylation Site Page: > Ser143  -  DVL2 (mouse)

Site Information
FHPNVSSsHENLEPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7320089

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ALK (human) ( 1 ) , CK1E (human) ( 1 ) , N-Myc (human) ( 1 )
Treatments:
alectinib ( 1 ) , heparin sodium ( 1 )

Downstream Regulation
Effects of modification on DVL2:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell differentiation, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DVL2 (human) ( 1 )

References 

1

Unno K, et al. (2021) Activated ALK Cooperates with N-Myc via Wnt/β-catenin Signaling to Induce Neuroendocrine Prostate Cancer. Cancer Res
33637566   Curated Info