Ser143
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Home > Phosphorylation Site Page: > Ser143  -  DVL2 (human)

Site Information
FHPNVSssHENLEPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7320089

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , modification-specific antibody ( 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , HCT116 (intestinal) ( 2 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 3 , 5 ) , hTERT-RPE1 (epithelial) ( 2 ) , Jurkat (T lymphocyte) ( 4 )

Upstream Regulation
Regulatory protein:
CK2A1 (human) ( 1 ) , WNT3A (human) ( 2 ) , WNT5A (human) ( 2 )
Putative in vivo kinases:
CK1D (human) ( 1 , 3 ) , CK1E (human) ( 1 , 3 )
Kinases, in vitro:
CK1D (human) ( 3 ) , CK1E (human) ( 3 )
Putative upstream phosphatases:
PPP5C (human) ( 2 )
Treatments:
BI2536 ( 3 ) , BMI-1026 ( 3 ) , cisplatin ( 1 ) , GSK-3_inhibitor_X ( 3 ) , IC261 ( 3 ) , silmitasertib ( 1 ) , siRNA ( 3 ) , VX-680 ( 3 ) , Wnt5a ( 3 )

Downstream Regulation
Effects of modification on DVL2:
intracellular localization ( 2 , 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell cycle regulation ( 2 ) , cytoskeletal reorganization ( 3 ) , signaling pathway regulation ( 1 )
Induce interaction with:
PLK1 (human) ( 3 )

References 

1

Jin C, Song P, Pang J (2019) The CK2 inhibitor CX4945 reverses cisplatin resistance in the A549/DDP human lung adenocarcinoma cell line. Oncol Lett 18, 3845-3856
31579410   Curated Info

2

Xie J, et al. (2018) PP5 (PPP5C) is a phosphatase of Dvl2. Sci Rep 8, 2715
29426949   Curated Info

3

Lee KH, et al. (2012) Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J 31, 3104-17
22609948   Curated Info

4

Mulhern D (2012) CST Curation Set: 13831; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) PKC Substrate (P-S3-101) Rabbit mAb Cat#: 6967, PTMScan(R) Phospho-PKC Substrate Motif (K/RXS*XK/R) Immunoaffinity Beads Cat#: 6970
Curated Info

5

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

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