Ser98
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Home > Phosphorylation Site Page: > Ser98  -  p21Cip1 (human)

Site Information
GGRRPGTsPALLQGT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478193

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , [32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 4 ) , mutation of modification site ( 2 , 3 , 4 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CDK4 (human) ( 2 )
Putative in vivo kinases:
ASK1 (human) ( 4 )
Kinases, in vitro:
ASK1 (human) ( 4 ) , CDK4 (human) ( 2 ) , ERK1 (human) ( 1 ) , ERK2 (human) ( 1 ) , JNK1 (human) ( 1 ) , JNK2 (human) ( 1 ) , JNK3 (human) ( 1 ) , P38A (human) ( 1 )
Treatments:
1NM-PP1 ( 2 ) , PD0332991 ( 2 ) , serum ( 2 )

References 

1

Colleoni B, et al. (2017) JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21. Oncogene 36, 4349-4361
28368408   Curated Info

2

Bisteau X, et al. (2013) CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point. PLoS Genet 9, e1003546
23737759   Curated Info

3

Densham RM, et al. (2009) MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol 29, 6380-90
19822666   Curated Info

4

Zhan J, et al. (2007) Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo. Mol Cell Biol 27, 3530-41
17325029   Curated Info