Ser114

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Home > Phosphorylation Site Page: > Ser114 - p21Cip1 (human)

Site Information
EEDHVDLsLSCTLVP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 478191

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	MCF-7 (breast cell) ( 1 ) , SK-MEL2 (melanocyte) ( 1 )

Upstream Regulation
Putative in vivo kinases:	GSK3B (human) ( 1 )
Kinases, in vitro:	GSK3B (human) ( 1 )
Treatments:	caffeine ( 1 ) , lithium ( 1 ) , siRNA ( 1 ) , TDZD-8 ( 1 ) , UV ( 1 )

Downstream Regulation
Effects of modification on p21Cip1:	protein degradation ( 1 )

References
1	Lee JY, et al. (2007) Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation. Mol Cell Biol 27, 3187-98 17283049 Curated Info

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