Thr1780

Site Information
DHGAEIItQsPGRss SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 478009

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 )
Disease tissue studied:	breast cancer ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 5 , 8 ) , non-small cell lung cancer ( 8 ) , pancreatic ductal adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:	'pancreatic, ductal'-pancreas ( 3 ) , 293 (epithelial) [AT1 (human), transfection] ( 6 ) , A498 (renal) ( 7 ) , breast ( 1 ) , CL1-0 (pulmonary) ( 5 ) , CL1-1 (pulmonary) ( 5 ) , CL1-2 (pulmonary) ( 5 ) , CL1-5 (pulmonary) ( 5 ) , endothelial-aorta ( 4 ) , HCT116 (intestinal) ( 9 ) , MCF-7 (breast cell) ( 2 ) , NCI-H1650 (pulmonary) ( 8 )

Upstream Regulation
Treatments:	metastatic potential ( 5 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290 27362937 Curated Info
3	Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948 24670416 Curated Info
4	Verano-Braga T, et al. (2012) Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res 11, 3370-81 22497526 Curated Info
5	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info
6	Xiao K, et al. (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 107, 15299-304 20686112 Curated Info
7	Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62 20071362 Curated Info
8	Possemato A (2010) CST Curation Set: 9744; Year: 2010; Biosample/Treatment: cell line, H1650/Phenformin; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XX[ST] Curated Info
9	Nagano K, et al. (2009) Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Proteomics 9, 2861-74 19415658 Curated Info