Thr847
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr847  -  CtIP (human)

Site Information
FRYIPPNtPENFWEV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7113805

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 5 , 6 ) , mutation of modification site ( 1 , 4 , 5 , 7 ) , phospho-antibody ( 1 , 7 ) , western blotting ( 1 , 7 )
Disease tissue studied:
bone cancer ( 7 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 6 ) , lymphocyte ( 4 ) , Sf21 ( 5 ) , U2OS (bone cell) ( 7 )

Upstream Regulation
Regulatory protein:
CtIP (human) ( 1 ) , USP52 (human) ( 1 )
Putative in vivo kinases:
CDK2 (human) ( 7 )
Kinases, in vitro:
CDK2 (human) ( 7 )
Treatments:
ionizing_radiation ( 1 ) , seliciclib ( 7 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 7 ) , cell growth, induced ( 4 ) , chromatin organization, altered ( 7 ) , DNA repair, induced ( 4 )

References 

1

Gao M, et al. (2020) USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP. Nat Commun 11, 5362
33097710   Curated Info

2

Nath S, Nagaraju G (2020) FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks. PLoS Genet
32251466   Curated Info

3

Ceppi I, et al. (2020) CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection. Proc Natl Acad Sci U S A
32241893   Curated Info

4

Liu X, et al. (2019) CtIP is essential for early B cell proliferation and development in mice. J Exp Med 216, 1648-1663
31097467   Curated Info

5

Makharashvili N, et al. (2014) Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection. Mol Cell 54, 1022-33
24837676   Curated Info

6

Guo A (2011) CST Curation Set: 12024; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

7

Huertas P, Jackson SP (2009) Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair. J Biol Chem 284, 9558-65
19202191   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.