Thr62
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Home > Phosphorylation Site Page: > Thr62  -  PDE6G (mouse)

Site Information
PGMEGLGtDITVICP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449335

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
GRK2 (mouse) ( 2 )
Treatments:
EGF ( 2 ) , thrombin ( 2 )

Downstream Regulation
Effects of modification on PDE6G:
activity, induced ( 2 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 , 2 )
Induce interaction with:
GRK2 (mouse) ( 1 )

References 

1

Wan KF, et al. (2003) The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. J Biol Chem 278, 18658-63
12624098   Curated Info

2

Wan KF, et al. (2001) The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. J Biol Chem 276, 37802-8
11502744   Curated Info