Thr22
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Home > Phosphorylation Site Page: > Thr22  -  PDE6G (mouse)

Site Information
RVIGGPVtPRKGPPK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449334

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 ) , retina ( 1 , 3 ) , retina [PDE6G (mouse), transgenic] ( 2 )

Upstream Regulation
Treatments:
light ( 1 )

Downstream Regulation
Effects of modification on PDE6G:
enzymatic activity, induced ( 3 ) , phosphorylation ( 4 )

References 

1

Janisch KM, et al. (2009) Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun 390, 1149-53
19878658   Curated Info

2

Woodruff ML, et al. (2008) Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors. J Neurosci 28, 2064-74
18305241   Curated Info

3

Tsang SH, et al. (2007) Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response. J Physiol 579, 303-12
17138607   Curated Info

4

Wan KF, et al. (2003) The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. J Biol Chem 278, 18658-63
12624098   Curated Info