Ser659
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Home > Phosphorylation Site Page: > Ser659  -  PER2 (mouse)

Site Information
TLPGKAEsVVsLTSQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449331

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
familial advanced sleep phase syndrome ( 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 , 4 ) , MEF (fibroblast) ( 3 )

Upstream Regulation
Putative in vivo kinases:
CK1D (mouse) ( 1 ) , CK1E (mouse) ( 1 )
Kinases, in vitro:
CK1D (mouse) ( 1 ) , CK1E (mouse) ( 1 )
Treatments:
D4476 ( 1 ) , PF-670462 ( 1 )

Downstream Regulation
Effects of modification on PER2:
intracellular localization ( 4 ) , protein degradation ( 3 ) , protein stabilization ( 4 )

References 

1

Narasimamurthy R, et al. (2018) CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. Proc Natl Acad Sci U S A 115, 5986-5991
29784789   Curated Info

2

Eng GWL, Edison, Virshup DM (2017) Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. PLoS One 12, e0177834
28545154   Curated Info

3

Zhou M, et al. (2015) A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. Mol Cell 60, 77-88
26431025   Curated Info

4

Vanselow K, et al. (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev 20, 2660-72
16983144   Curated Info