Ser376
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Home > Phosphorylation Site Page: > Ser376  -  SLP76 (mouse)

Site Information
IGFQQSAsLPPYFSQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 476784

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
T lymphocyte ( 2 ) , T lymphocyte-spleen ( 1 )

Upstream Regulation
Putative in vivo kinases:
HPK1 (human) ( 2 )
Treatments:
antibody ( 2 )

Downstream Regulation
Effects of modification on SLP76:
molecular association, regulation ( 2 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 2 )
Induce interaction with:
14-3-3 zeta (human) ( 2 )
Inhibit interaction with:
LAT (human) ( 2 )

References 

1

Wang X, et al. (2012) Attenuation of T Cell Receptor Signaling by Serine Phosphorylation-mediated Lysine 30 Ubiquitination of SLP-76 Protein. J Biol Chem 287, 34091-100
22902619   Curated Info

2

Lasserre R, et al. (2011) Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation. J Cell Biol 195, 839-53
22105350   Curated Info